心肌肌钙蛋白I自身抗体和心血管系统疾病

Anti-cardiao troponin I autoantibody and diseases of cardiovascular system

心肌肌钙蛋白I自身抗体(cTnIAAb)可在心肌损伤患者循环中出现。血清中cTnIAAb不仅会对cTnI检测产生负性干扰,还可能延迟急性冠脉综合征(ACS)的治疗。cTnIAAb在心脏病的发病机制中所起到的作用还有待阐明。未来的研究方向将专注于cTnIAAb的病理作用及机制研究,可能对ACS、心肌损伤后心肌炎、扩张型心肌病和心力衰竭等的定向治疗带来益处。

Anti-heart autoantibodies have been identified in patients with heart disease.The presence of antitroponin I autoantibodies in the serum may cause a false-negative evaluation of troponin I levels and delay treatment of acute coronary syndrome.The role of anti-troponin I autoantibodies in humans and their possible involvement in the pathogenesis of heart disease remains controversial.Future research should focus on the pathogenic role of anti-troponin I autoantibodies and the possible benefits of targeted therapy in acute coronary syndrome,post-myocardial infarction,myocarditis,dilated cardiomyopathy and heart failure.