血清H-FABP和cTnT水平联合测定在急性心肌梗死诊断中的作用

The role of combined detection of serum H-FABP and cTnT levels in the diagnosis of acute myocardial infarction

目的:研究心肌损伤标志物心型脂肪酸结合蛋白(H-FABP)和心肌肌钙蛋白T(cTnT)联合检测在急性心肌梗死(AMI)临床诊断中的作用和意义。方法:采用ELISA方法对33例AMI患者(AMI组)和31例正常对照者(对照组)血清中的H-FABP和cTnT浓度进行测定,比较两组血清样本中H-FABP与cTnT的浓度,并考察HFABP、cTnT及其组合的诊断灵敏度、特异度以及诊断准确率。结果:与对照组相比,AMI组患者血清H-FABP和cTnT浓度均显著增高(P<0.05)。H-FABP、cTnT、H-FAB+cTnT的灵敏度分别为60.61%、75.76%、96.97%,特异度分别为:83.55%、85.77%、93.55%,诊断准确率分别为85.94%、85.94%、95.31%。结论:血清H-FABP和cTnT浓度联合测定可为临床AMI患者的确诊提供准确的实验室依据,有助于减少漏诊及误诊。

Objective：To study the clinical significance of myocardial injury markers cardiac fatty acid binding protein（H-FABP）and cardiac troponin T（cTnT）in clinical diagnosis of acute myocardial infarction（AMI）.Method：The serum H-FABP and cTnT levels in 33 patients with AMI（AMI group）and 31 normal controls（control group）were determined by double sandwich enzyme-linked immunosorbent assay（ELISA）.Then levels of HFABP and cTnT in the two groups were compared,and the sensitivity,specificity,diagnose accordance rate of the indexes were investigated.Result：Compared with normal control group,AMI group had significantly higher serum H-FABP and cTnT concentrations（P0.05）.The sensitivity of H-FABP,cTnT and H-FAB plus cTnT were60.61%,75.76% and 96.97% respectively.The specificity were 83.55%,85.77% and 93.55% respectively.The diagnose accordance rate were 85.94%,85.94% and 95.31% respectively.Conclusion：The combined determination of serum H-FABP and cTnT can provide accurate laboratory basis for the diagnosis of AMI,which is helpful to reduce misdiagnosis and misdiagnosis.