期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PCSK9基因多态性与心血管疾病相关性的研究进展 被引量：4

Advances on the relationship between PCSK9 gene polymorphisms and cardiovascular diseases
原文传递
导出
摘要 前蛋白转化酶枯草溶菌素-9(PCSK9)能通过调节细胞膜表面低密度脂蛋白受体,影响血脂代谢,并参与动脉粥样硬化过程。近年来研究表明,PCSK9基因多态性可能与血脂异常及心血管疾病有关。现就PCSK9基因多态性与心血管疾病的研究进展做一综述。 The proprotein convertase subtilisin/kexin type 9（PCSK9）can affect the lipids metabolism and take part in the process of atherosclerosis by modulating the low-density lipoprotein receptor in cell membrane.The recent researches showed that PCSK9 gene polymorphisms might be associated with dyslipidemia and cardiovascular diseases.This article reviews the recent advances on the relationship between PCSK9 gene polymorphisms and cardiovascular diseases.
作者 蔡高军 王绿娅
机构地区 江苏大学附属武进医院心内科 首都医科大学附属北京安贞医院心肺血管疾病研究所
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2017年第7期708-711,共4页 Journal of Clinical Cardiology
基金 常州市武进区科技发展项目(No:WS201603)
关键词 前蛋白转化酶枯草溶菌素-9 基因 多态性 心血管疾病 proprotein convertase subtilisin/kexin type 9 gene polymorphism cardiovascular diseases
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

二级参考文献82

  • 1Jirholt P,Adiels M,Bore'n J.How does mutant proprotein convertase neural apoptosis-regulated convertase 1 induce autosomal dominant hypercholesterolemia [ J ]. Arterioscler Thromb Vasc Biol,2004,24(8) : 1334-1336.
  • 2Berge KE,Ose L,Leren TP.Missense mutations in the PCSK 9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy [J].Arterioscler Thromb Vasc Biol, 2006,26(5) : 1094-1100.
  • 3Chen SN,Ballantyne CM,Gotto AM,et al.Acommon PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronaryatherosclerosis [J].J Am Coil Cardiol,2005,45(10) : 1611-1619.
  • 4Kotowski IK, Pertsemlidis A, Luke A, et al.A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol [J].Am J Hum Genet, 2006,78 (3) : 410-422.
  • 5Scartezini M,Hubbart C,Whittall RA,et al.The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy UK men [J].Clin Sci (Lond), 2007, 113 (11):435-441.
  • 6Polisecki E,Peter I,Robertson M,et al.Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population [ J ].Atherosclerosis, 2008,200 ( 1 ) : 95-101.
  • 7Evans D,Beil FU.The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women [ J ].BMC Med Genet, 2006,7 : 66.
  • 8Abifadel M,Varret M, Rabes JP,et al.Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].Nat Genet,2003,34 (2) : 154-156.
  • 9Timms KM,Wagner S,Samuels ME,et al.A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree [ J ].Hum Genet, 2004,114 (4) : 349-353.
  • 10Miyake Y, Kimura R, Kokubo Y, et al.Genetic variants in PCSK9 in the Japanese population:rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population [ J ].Atherosclerosis, 2008,196 ( 1 ) : 29-36.

共引文献40

同被引文献20

引证文献4

二级引证文献10

临床心血管病杂志
2017年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部