儿童幽门螺杆菌感染相关性胃炎外周血Th17/Treg水平检测及意义

Significance of Blood Levels of Th17/Treg for Children's Gastritis with Hp Infection

目的探讨儿童幽门螺杆菌(Helicobacter pylori,Hp)感染相关性胃炎外周血Th17/Treg主要效应因子的水平及意义。方法采用前瞻性研究方法,收集笔者医院儿科门诊自2015年1月~2016年6月间收治的40例Hp感染性相关胃炎患儿作为观察组,选取同期在笔者医院健康体检的40例Hp阴性患儿作为健康对照组,对两组Th17/Treg主要效应因子的水平和观察组治疗前后主要效应因子水平变化进行比较,并对Th17与Treg主要效应因子进行相关性分析。结果观察组和健康对照组血浆IL-17、IL-10及TGF-β水平进行比较,差异有统计学意义(P<0.05);治疗后10天,观察组治疗前后血浆IL-17、IL-10及TGF-β水平进行比较,差异有统计学意义(P<0.05);治疗前,观察组血浆IL-17与IL-10及TGF-β水平进行相关性分析,IL-17与IL-10呈负相关(r=-0.778);IL-17与TGF-β呈负相关(r=-0.767)。结论在儿童Hp感染性相关胃炎的发生、发展过程中,Th17和Treg相关细胞因子参与了免疫病理过程。为儿童Hp感染相关性胃炎免疫防治提供新的思路。

Objective To explore the significance of the main effect factors of Th17/Treg for children＇s gastritis with Hp infection. Methods By prospective study method, 40 cases of helicobacter pylori infection related gastritis children were collected as observation group from January 2015 to June 2016, 40 cases of children with Hp negative were selected in the same period by physical examination as healthy controls. The main effect factors of Th17/Treg of the two groups were compared. Before and after the treatment, the main effect factors of Th17/Treg of observation group were compared. The main effect factors of Th17/Treg had a correlation analysis. Results The serum IL - 17, IL - 10 and TGF - beta levels of two groups were compared, and the difference was statistically significant （ P 〈 0.05 ）. Be- fore and after 10 days treatment, serum IL - 17 ,IL - 10 and TGF - beta levels of the observation group were compared, and the difference was statistically significant （ P 〈 0.05 ）. Before the treatment, the serum IL - 17 ,IL - 10 and TGF - beta levels of observation group had a correlation analysis, and IL - 17 and IL - 10 were negatively correlated （ r = 0. 778）. IL - 17 and TGF - beta were also negatively corre- lated（r = 0. 767）. Conclusion In development process of Hp infection related gastritis for children,the related factors of Thl7 and Treg cells involved in the immune pathological process. Immune prevention for children＇s gastritis with Hp infection provides new train of thought.