来曲唑与尿促性素在多囊卵巢综合征不孕患者促排卵中的应用

Application of Letrozole and Human Menopausal Gonadotmpin Forovulation Induction in Infertile Women with Polycystic Ovary Syndrome

目的分析来曲唑(letrozole,LE)与尿促性素(human menopausal gonadotmpin,HMG)在多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕患者促排卵中的疗效。方法选取112例多囊卵巢综合征不孕患者,分为A、B两组,A组(来曲唑组)、B组(来曲唑与尿促性素组),B组HMG用法为隔日肌内注射1次。观察两组成熟卵泡数、成熟卵泡率、排卵率、临床妊娠率、异位妊娠数及早期流产率等。结果两组基础性激素水平、BMI、成熟卵泡数、排卵率差异均无统计学意义(P>0.05);妊娠率两组分别为26.7%和41.6%,差异有统计学意义(P=0.046),说明B组临床妊娠率优于A组;B组中HMG的周期平均用量为5.12支(532/104)。A组3例早期流产,3例多胎妊娠;B组2例自然流产,1例异位妊娠,5例多胎妊娠,差异无统计学意义(P>0.05)。结论对于多囊卵巢综合征不孕患者进行促排卵治疗,LE与HMG联合应用且HMG隔日肌内注射1次的方案优于单用LE。

Objective To analyze the effect of different treatment for ovulation induction with letrozole （LE） and human menopausal Gonadotmpin（HMG） in infertile women with polycystic ovary syndrome. Methods Totally 112 cases of infertile women with polyeystic o- vary syndrome were divided into two groups： group A （LE） , groupB （LE ＋ HMG）. The usage of HMG for group B is to apply intramuscular injection every other day. The number of mature follicle, mature follicle rate, ovulation rate, clinical pregnancy rate, ectopic pregnancy rate and the early abortion rate of HCG wasmeasured. Results In this study, there was no significant difference in basal hormone levels, BMI, the number of mature follicles and ovulation rate between the two groups（ P 〉 0.05 ）. The pregnancy rate of 2 groups were 26.7% and 41.6% （ P = 0. 046）. The difference was statistically significant, indicating that group B was better than group A in pregnancy rate. The average amount of HMG in group B was 5.12 （532/104）. In group A, there were 3 cases of early abortion,3 cases of multiple preg- nancy, while in group B, there are 2 cases of spontaneous abortion, I cases of ectopic pregnancy, 5 cases of multiple pregnancy. Conclu- sion For infertile women with polycystic ovary syndrome, ovulation induction, the program of LE combine with HMG by intramuscular in- jection every other day is better than single use of LE.