基质金属蛋白酶-9及张力蛋白同源基因在牙龈癌中的表达以及临床意义

Expression of matrix metalloproteinase-9 and tension protein homologous gene（PTEN） in gingival carcinoma and its clinical significance

目的探讨基质金属蛋白酶（MMP）-9以及张力蛋白同源基因（PTEN）在牙龈癌组织的表达情况及临床意义。方法选取固原市人民医院2013年6月~2016年12月就诊的牙龈癌患者50例,研究MMP-9以及PTEN在牙龈癌组织的表达。结果牙龈癌组中PTEN的阳性率为54.00%,正常组织PTEN的阳性率为94.00%,正常对照组PTEN阳性率明显高于牙龈癌组（P〈0.05）;牙龈癌组中MMP-9的阳性率为76.00%,正常对照组的阳性率为20.00%,牙龈癌组明显高于正常对照组（P〈0.05）。MMP-9与PTEN在牙龈癌组织的表达与性别、年龄、组织分化无关,与淋巴结转移、组织浸润情况相关（P〈0.05）。结论 PTEN在牙龈癌组织中低表达,MMP-9在牙龈癌组织中呈高表达。PTEN、MMP-9与牙龈癌的发生、发展密切相关。因此提示MMP-9阳性是牙龈癌的危险因素,而PTEN阳性则是牙龈癌的保护因素。

Objective To investigate the expression and clinical significance of matrix metalloproteinase（ MMP-9） and tension protein homologous gene in gingival cancer tissue. Methods 50 cases in Guyuan people＇s hospital from June 2013 to December 2016 were selected to study the expression of matrix metalloproteinase（ MMP-9） and tension protein homologous gene in gingival cancer tissue. Results The positive rate of PTEN in gingival cancer group was 54. 00%,the positive rate of PTEN was 94. 00% in normal tissue,normal control group positive rate of PTEN was significantly higher than that of gingival cancer group（ P〈 0. 05）; the positive rate of MMP-9 in gingival cancer group was 76. 00%,the positive rate of control group was20. 00%,gingival cancer group was significantly higher than the normal control group（ P 〈0. 05）. The expression of MMP-9 and PTEN in in gingival cancer tissue was unrealted with gender,age,and tissue differentiation,and associated with lymph node metastasis and tissue infiltration（ P〈 0. 05）.Conclusion PTEN expression is low in gingival cancer tissue low,MMP-9 expression is high in gingival cancer tissues. PTEN and MMP-9 are closely related to the incidence and development of gingival cancer. Therefore,MMP-9 positivity is a risk factor for gingival cancer,while PTEN positivity is a protective factor for gingival cancer.