康复新口服液对口腔溃疡患者疼痛缓解,唾液SIgA水平、IgG水平的影响

Effect of Kangfuxin Liquid on pain relief,saliva SIgA level and IgG level in patients with oral ulcer

目的探讨应用康复新口服液对口腔溃疡患者疼痛缓解,唾液SIgA水平、IgG水平的影响。方法选取本院口腔科2013年1月~2015年7月治疗的98例口腔溃疡患者,随机分为2组,每组49例。观察组使用康复新口服液治疗,对照组采用口腔炎喷雾剂治疗。观察2组采取不同疗法后治疗效果、疼痛缓解、溃疡愈合时间及唾液中SIgA、IgG水平变化,且记录是否并发副作用。结果观察组治疗有效率89.79%高于对照组65.30%（P〈0.05）。与治疗前对比,观察组治疗后唾液SigA水平升高,IgG水平下降（P〈0.05）,对照组治疗后唾液SIgA、IgG水平改善幅度大于对照组,差异有统计学意义（P〈0.05）。观察组治疗后疼痛缓解及愈合时间明显短于对照组（P〈0.05）。结论康复新口服液治疗口腔溃疡临床疗效显著,减少局部口腔溃疡处灼痛感,促进溃疡坏死细胞脱落及肉芽组织新生,增加SIgA、IgG含量,加强局部免疫反应,使溃疡加速愈合,值得推广。

Objective To investigate the application effect of Kangfuxin Liquid on pain relief saliva SigA and IgG levels in patients with oral ulcer.Methods A total of 98 patients with oral ulcer treated in our hospital from January 2013 to July 2015 were randomly divided into two groups,with 49 cases in each group. The observation group was treated with Kangfuxin oral liquid,the control group was treated with stomatitis spray. The treatment effect,relieve pain,ulcer healing time and saliva SIgA,IgG levels in the two groups were observed,and whether the record of concurrent side effects.Results The effective rate of the treatment group was 89. 79% higher than the control group 65. 30%（ P〈 0. 05）. Compared with before treatment,the observation group after treatment,the level of saliva SigA increased,IgG level decreased（ P 〈0. 05）,the control group after treatment of saliva SIgA,IgG level of improvement is greater than that of the control group,the difference was statistically significant（ P〈 0. 05）. The pain relief and healing time of the observation group were significantly lower than the control group（ P 〈0. 05）. Conclusion The clinical effect of Kangfuxin liquid in treatment of oral ulcer in patients with significant clinical effect,reduce local ulcer pain,promote ulcer necrotic cell shedding and granulation tissue of newborn,increase the SIgA,IgG content,strengthen the local immunity response,promote oral ulcer healing,worthy of promotion.