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参附青注射液联合糖皮质激素在脓毒症休克治疗中的应用效果观察

Effectof Shenfuqing injection combined with glucocorticoidon the treatment of septic shock
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摘要 目的观察参附青注射液联合糖皮质激素在脓毒症休克治疗中的应用效果。方法选取四川省人民医院城东病区肝胆胰外科于2013年10月~2015年6月收治的脓毒症休克患者共93例,随机分为观察组47例和对照组46例。对照组在抗感染治疗的基础上给与糖皮质激素治疗,观察组在抗感染治疗的基础上给与参附青注射液联合糖皮质激素治疗。随访并记录2组患者急性生理与慢性健康评分(APACHE-II评分)、降钙素原(PCT)、超敏C反应蛋白(hs-RP)、白介素-10(IL-10)、白介素-1(IL-1)、白介素-6(IL-6)、及治疗疗效情况。结果观察组患者治疗后APACHE-II评分、PCT分别为(41.69±6.25)分、(3.01±0.73)ng/mL,均低于对照组(52.19±7.06)分、(4.52±1.04)ng/mL,且差异具有统计学意义(P〈0.05)。观察组患者治疗后hs-CRP和IL-10水平分别为(16.38±2.45)mg/L、(26.08±3.34)pg/mL,均低于对照组(21.69±3.02)mg/L、(32.18±4.17)pg/mL,且差异具有统计学意义(P〈0.05)。观察组患者治疗后IL-1和IL-6水平分别为(6.49±2.00)ng/L、(15.62±5.67)pg/mL,均低于对照组(10.45±2.26)ng/L、(26.19±7.02)pg/mL,且差异具有统计学意义(P〈0.05)。观察组治疗后总有效率为74.47%,明显低于对照组52.17%,且差异具有统计学意义(P〈0.05)。结论参附青注射液联合糖皮质激素治疗脓毒症休克,可明显降低患者血液中炎症因子水平,缓解患者症状。 Objective To observe the effect of Shenfuqing injection combined with glucocorticoidonthe treatment of septic shock. Methods 93 cases from October 2013 to June 2015 were randomly divided into the observation group( 47 cases) and the control group( 46 cases). On the basis of anti infection,the observation group were given Shenfu injection combined with green glucocorticoid,and the control group were given glucocorticoid. Acute physiology and chronic health evaluation( APACHE-II score),down calcium original( PCT),high-sensitivity C-reactive protein( hs-CRP),interleukin-10( IL-10),interleukin-1( IL-1),interleukin-6( IL-6),and effect in the two groups were followed-up and compared. Results APACHE-II score,PCT respectivelywere( 41. 69 ± 6. 25) points and( 3. 01 ± 0. 73) ng/mL,which were lower than( 52. 19 ± 7. 06) points and( 4. 52 ± 1. 04) ng/mL in the control group,and the difference is significant( P〈 0. 05). hs-CRP and IL-10 were( 16. 38 ± 2. 45) mg/L and( 26. 08 ± 3. 34) pg/mL in the observation group,which were lower than( 21. 69 ± 3. 02) mg/L and( 32. 18 ± 4. 17) pg/mL in the control group,the difference was significant( P 〈0. 05). IL-1and IL-6 were( 6. 49 ± 2. 00) ng/Land( 15. 62 ± 5. 67) pg/mL in the observation group,which were lower than( 10. 45 ± 2. 26) ng/L and( 26. 19 ±7. 02) pg/mLin the control group,and the difference was significant( P 〈0. 05). The total effective rate was 74. 47%,which was significantly lower than 52. 17% in the control group, and the difference was significant( P〈 0. 05). Conclusion It which Shenfuqing injection combined with glucocorticoid was use in the treatment of septic shock can significantly reduce the inflammatory factors,relieve symptoms.
出处 《中国生化药物杂志》 CAS 2017年第7期47-49,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 糖皮质激素 脓毒症休克 炎症因子 参附青注射液 glucocorticoid septic shock inflammatory factor Shenfuqing injection
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