诺雷德针联合散结镇痛胶囊治疗子宫内膜异位症的临床疗效观察

clinical curative effect observation on treatment of endometriosis with Zoladex needle combined with Sanjiezhentong capsule

目的观察诺雷德与散结镇痛胶囊联合治疗子宫内膜异位症的临床疗效。方法选取永康市妇幼保健院妇科2016年1月~2016年12月收治的80例子宫内膜异位症患者随机分为2组,每组40例。研究组给予诺雷德针与散结镇痛胶囊治疗;对照组给予诺雷德针治疗。比较2组前列腺素F2a（PCF2a）、CA125、视觉模拟评分（VAS）、临床疗效、不良反应。结果治疗后,研究组PCF2a、CA125的改善程度均显著大于对照组,差异具有统计学意义（t=4.167,t=3.533,P〈0.05）。2组VAS评分进行比较,差异无统计学意义（t=0.961,P〉0.05）。研究组总有效率90.00%,对照组75.00%,差异具有统计学意义（χ~2=5.741,P〈0.05）。研究组出现不良反应4例（10.00%）,对照组10例（25.00%）,差异具有统计学意义（χ~2=7.792,P〈0.05）。结论诺雷德针联合散结镇痛胶囊可有效减轻子宫内膜异位症患者引起的疼痛,减少不良反应,显著提高临床疗效,适合在临床中深入研究使用。

Objective To observe the clinical curative effect of Zoladex combined with Sanjie analgesic capsule in treatment of endometriosis.Methods 80 patients with endometriosis treated in our hospital from January 2016 to December 2016 were randomly divided into two groups,with 40 cases in each group. The study group was given Zoladex needle and Sanjiezhentong capsule treatment; The control group were given Sanjie Zhentong capsule. Prostaglandin F2a（ PCF2a）,CA125,visual analogue scale（ VAS）,clinical efficacy and adverse reactions were compared between the two groups. Results After treatment,the PCF2 a and CA125 in the study group were significantly higher than those in the control group,the difference was statistically significant（ t = 4. 167,t = 3. 533,P〈 0. 05）. There was no significant difference in VAS score between the two groups（ t = 0. 961,P〉 0. 05）. The total effective rate of the study group was 90%,and the control group was 75%,the difference was statistically significant（ χ~2= 5. 741,P 〈0. 05）.,there were 4 cases of adverse reactions（ 10%） in the study group,and 10 cases in the control group（ 25%）,the difference was statistically significant（ χ~2= 7. 792,P〈 0. 05）. Conclusion Zoladex needle combined with Sanjiezhentong capsule,can effectively relieve the pain caused by endometriosis,reduce adverse reaction,improve the clinical efficacy,suitable for use in clinical research.