蛭丹化瘀汤对颈动脉粥样硬化斑块患者的临床效果

The clinical effect of zhidanhuayu Decoction on patients with carotid atherosclerotic plaque

目的观察蛭丹化瘀汤对颈动脉粥样硬化斑块患者的临床疗效。方法选择80例颈动脉粥样硬化的患者,采用随机数字表法随机分为2组,每组40例,对照组治疗方案：瑞舒伐他汀钙20 mg,每晚1次。治疗组在对照组方案基础上每晚一次的基础上加用蛭丹化瘀汤剂,上药1剂加清水500 mL温火煎至200 mL,再加清水200 mL煎至100 mL,两煎相兑,上下午各半量分服,1天/剂;2组均以3个月为1个疗程。对比治疗前后内-中膜厚度（IMT）,粥样硬化斑块积分、血脂以及不良反应等。结果 2组治疗前后比较内-中膜厚度（IMT）,粥样硬化斑块积分、血脂差异均有统计学意义（P〈0.05）。组间治疗后比较,治疗组与对照组比较,IMT、斑块积分、血脂均有统计学意义（P〈0.05）。结论蛭丹化瘀汤不仅有调整血脂的作用,还具有抗动脉粥样硬化的作用。

Objective To observe the clinical curative effect of zhidanhuayu decoction on patients with carotid atherosclerotic plaque.Methods 80 patients with carotid atherosclerosis were randomly divided into two groups,each group of 40 cases,the control group was treated with rosuvastatin calcium 20 mg,once every night. The treatment group in the control group on the basis of a scheme based on the use of night zhidanhuayu decoction water 500 mL temperature and heat to 200 mL,then add water and cook until 200 mL to 100 mL,on the afternoon of two phase decoction against half amount of clothes,a daily agent; the two groups were 3 months for 1 courses. Before and after treatment,the mean medial thickness（ IMT）,plaque score,blood lipid and adverse reactions were observed. Results There was significant difference between the two groups before and after treatment,the difference was significant between the medial and middle thickness（ IMT）,plaque score and blood lipid（ P〈 0. 05）. After treatment,compared with the control group,the treatment group and the control group,IMT,plaque score,blood lipids were statistically significant（ P 〈0. 05）.Conclusion Zhidanhuayu decoction can adjust the blood lipids,but also has the effect of anti atherosclerosis.