灯盏花素联合阿司匹林对老年冠心病患者阿司匹林抵抗的影响

Effects of breviscapine combined with aspirin on aspirin resistance in elderly patients with coronary heart disease

目的探讨灯盏花素联合阿司匹林对老年冠心病患者阿司匹林抵抗和临床效果的影响。方法选取2014年1月~2015年12月在湖州市南浔区中西医结合医院就诊的老年冠心病心绞痛患者178例,随机分为2组,每组89例。对照组给予拜阿司匹林100 mg口服治疗,研究组在对照组的基础上给予灯盏花素片口服。治疗6个月后,观察2组阿司匹林抵抗率、血液流变学指标、血清脂质过氧化物（LPO）、超氧化物歧化酶（SOD）、同型半胱氨酸（Hcy）、超敏-C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平,统计2组临床疗效和终点事件发生率。结果研究组治疗后阿司匹林抵抗率、全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数、纤维蛋白原、LPO、Hcy、hs-CRP、IL-6水平及终点事件发生率均低于对照组（P〈0.05）,SOD水平和临床有效率高于对照组（P〈0.05）。结论灯盏花素联合阿司匹林治疗老年冠心病心绞痛可降低阿司匹林抵抗,提高临床效果,降低终点事件发生率,具有临床推广价值。

Objective To investigate the effect of breviscapine combined with aspirin on aspirin resistance and clinical effect in elderly patients with coronary heart disease. Methods A total of 178 patients with angina pectoris treated in our hospital from January 2014 to December 2015 were randomly divided into two groups,with 89 cases in each group. The control group received 100 mg oral administration of aspirin. The study group was given breviscapine tablets oral on the basis of the control group. After six months of treatment,aspirin resistance,hemorheology,serum lipid peroxides（ LPO）,superoxide dismutase（ SOD）,homocysteine（ Hcy）,hypersensitivity C-reactive protein（ hs-CRP） and interleukin-6（ IL-6） were measured. The incidence of clinical efficacy and end points was statistically analyzed. Results The rates of aspirin resistance,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,erythrocyte aggregation index,fibrinogen,LPO,Hcy,hs-CRP,IL-6 levels and end point events in the study group were lower than the control group（ P 〈0. 05）. The level of SOD and the clinical efficiency were higher than those of the control group（ P〈 0. 05）.Conclusion Breviscapine combined with aspirin in the treatment of senile coronary heart disease can reduce aspirin resistance,improve clinical effect,reduce the incidence of end points,with clinical value.