黄芪辅助治疗慢性精神分裂症伴代谢综合征对患者抗氧化能力和肝肾功能的影响

Effect of Astragalus membranaceus on antioxidant capacity and liver and kidney function in patients with chronic schizophrenia and metabolic syndrome

目的探讨黄芪辅助治疗慢性精神分裂症伴代谢综合征对患者抗氧化能力及对肝肾功能的影响。方法以110例诊断慢性精神分类症伴代谢综合征患者为研究对象,采用随机数字表分为对照组与观察组,2组均予以常规抗精神病药,观察组在对照组用药基础上加用黄芪注射液,每天1次,10~14 d为1个疗程,共治疗6个疗程。疗程结束后比较2组治疗前后抗氧化能力及肝肾功能,并采用阳性与阴性症状量表（PANSS）评分量表评估患者精神症状。结果治疗后,2组抗氧化能力SOD、T-AOC较治疗前明显升高,MDA明显下降,且观察组变化幅度明显优于对照组;肝肾功能指标较治疗前均明显升高,除BUN、SUA组间比较差异无统计学意义,其他指标组间比较,观察组均优于对照组（P〈0.05）;治疗后对照组PANSS评分为（61.4±7.8）分,明显高于观察组的（54.5±8.2）分（P〈0.05）。结论黄芪可作为精神分裂症伴代谢综合征患者辅助治疗药,可有效提高机体抗氧化能力,并减轻肝肾功能损伤,改善精神疾病症状情况,从而提高生活质量,临床可予以考虑。

Objective To investigate the effect of Astragalus membranaceus on the antioxidant capacity and liver and kidney function in patients with chronic schizophrenia and metabolic syndrome. Methods 110 cases of patients with chronic schizophrenia and metabolic syndrome were selected as subjects. They were randomly divided into the control group and the observation group by random number table method. Both groups were treated with routine antipsychotic drugs,and the observation group were additionally treated with Astragalus injection,once per day. 10 ~ 14 d as a course of treatment,they were treated for a total of 6 courses. The antioxidant capacity and the liver and kidney function were compared between the two groups. The mental symptoms was evaluated with the positive and negative symptoms scale（ PANSS）. Results After treatment,the antioxidant capacity of the two groups was significantly increased while MDA was significantly decreased,and the changes were more obvious in observation group than the control group. After treatment,indexes of liver and kidney function were significantly increased. Except BUN and SUA,the other indicators were better in the observation group than the control group（ P〈 0. 05）. After treatment,PANSS score（ 61. 4 ± 7. 8） in the control group was significantly higher than that of the observation group（ 54. 5 ± 8. 2）（ P〈 0. 05）. Conclusion Astragalus membranaceus can be used as an assisted drug for treating chronic schizophrenia and metabolic syndrome. It can effectively improve the antioxidant capacity,reduce the damage to liver and kidney function and improve symptoms of mental illness,so as to improve the quality of life.