围手术期应用氨溴索联合心理干预对胸腔镜下肺叶切除术后肺癌患者的作用

Effect of periopusside administration of ambroxol combined with psychological intervention on patients with lung cancer after thoracoscopic lobectomy

目的探究围手术期应用氨溴索联合心理干预对胸腔镜下肺叶切除术后肺癌患者的作用。方法本次实验选取了2015年11月~2016年11月在山西省肿瘤医院就诊并确诊的50例行胸腔镜下肺叶切除术的肺癌患者,根据患者入院时间随机进行分组,分为实验组和对照组,各25例。实验组采用氨溴索处理自手术当天至术后3 d静脉给予盐酸氨溴索注射液600 mg/d,对照组采用同体积的生理盐水进行治疗。同时实验组进行心理干预治疗,对患者的心理进行必要的疏导。研究对资料进行收集并对比2治疗组术前一般资料、术中情况、手术前后的肺功能和血气分析结果、机械通气时间、术后早期并发症、术后住院时间及治疗费用等。结果围手术期内未出现死亡病例,实验组和对照组相比虽术后并发症的总发生率差异不够显著,但是肺部并发症显著减少,仅为1例,而对照组为9例。除此之外,在术后机械通气、ICU时间、术后住院时间、总治疗费用,2组数据差异显著,具有统计学意义（P〈0.05）。结论对胸腔镜下肺叶切除术的肺癌患者在围手术期采用大剂量静脉盐酸氨溴索注释液,可大大改善患者术后肺功能,降低术后并发症的出现,有效缩短术后住院时间,患者的物质压力进一步得到降低。

Objective To investigate the effect of perindox administration combined with psychological intervention on patients with lung cancer after thoracoscopic lobectomy. Methods Fifty patients with lung cancer underwent thoracoscopic lobectomy from November 2015 to November 2016 in our hospital were randomly divided into experimental group and experimental group according to the time of hospitalization. Control group,25 cases. The rats in the experimental group were treated with ambroxol hydrochloride（ 600 mg/d） from the day of operation to the postoperative 3d administration. The control group was treated with the same volume of saline. At the same time,the experimental group was treated with psychological intervention and the necessary psychological guidance was carried out. The data were collected and compared with the two groups before and after the general information,intraoperative conditions,lung function before and after surgery and blood gas analysis results,mechanical ventilation time,early postoperative complications,postoperative hospital stay and treatment costs. Results There were no cases of death in the perioperative period. Compared with the control group,the total incidence of postoperative complications was not significant,but the pulmonary complications were significantly reduced,only 1case and 9 cases in the control group The In addition,the postoperative mechanical ventilation,ICU time,postoperative hospital stay,total treatment costs,the difference between the two groups was significant,the data were statistically significant（ P〈 0. 05）. Conclusion The patients with lung cancer underwent thoracoscopic lobectomy with high dose intravenous ambroxol hydrochloride in the perioperative period can greatly improve the postoperative pulmonary function and reduce the postoperative complications,and effectively reduce the postoperative hospitalization Time,the material pressure on the patient is further reduced.