盐酸米诺四环素软膏对龈沟液中胶原酶的影响

Effects of Minocycline Hydrochloride Ointment on Collagenase in Gingival Crevicular Fluid

目的探讨盐酸米诺四环素软膏对龈沟液中胶原酶的影响。方法选取2015年1月~2016年12月于丽水市中医院诊治的慢性牙周炎患者60例作为研究对象,将患者以其干预方式分为2组,每组30例。对照组用超声洁治＋碘甘油治疗,观察组用超声洁治＋盐酸米诺四环素软膏治疗;比较2组患者各项实验数据。结果观察组患者治疗后龈沟液量、菌斑指数、探诊深度、附着丧失等指标变化情况优于对照组,组间比较差异有统计学意义（P〈0.05）;观察组患者临床治疗效果（93.3%）优于对照组（73.3%）,组间比较差异有统计学意义（P〈0.05）;观察组患者不良反应发生率（10.0%）低于对照组（26.7%）,组间比较差异有统计学意义（P〈0.05）。结论盐酸米诺四环素软膏可影响龈沟液中胶原酶水平,治疗慢性牙周炎的临床效果显著。

Objective To investigate the effects of minocycline hydrochloride ointment on collagenase in gingival crevicular fluid. Methods 60 patients with chronic periodontitis treated in our hospital from January 2015 to December 2016 were selected as the research object,the patients were divided into two groups according to their intervention methods,30 cases in each group. The control group was treated with ultrasound clean governance and iodine glycerol,the observation group was treated with ultrasound clean governance and minocycline hydrochloride ointment The experimental data of the two groups were compared. Results The index change of gingival crevicular fluid volume plaque index,,depth of exploration and clinical attachment loss in the observation group were better than those in the control group,the difference between the two groups was statistically significant（ P 0. 05）;The clinical therapeutic effect of the observation group（ 93. 3%） was better than that of the control group（ 73. 3%）,and the difference between the two groups was statistically significant（ P〈 0. 05）. The incidence of adverse reactions in the observed group（ 10. 0%） was lower than that in the control group（ 26. 7%）,and the difference between the two groups was statistically significant（ P〈 0. 05）. Conclusion Minocycline hydrochloride ointment can affect the level of collagenase in gingival crevicular fluid,and the clinical effect of the treatment of chronic periodontal disease is significant.