联合应用毛果芸香碱与噻吗心安滴眼液治疗青光眼的合理给药

Combined administration of pilocarpine and timolol eye drops for the treatment of glaucoma

目的分析联合应用毛果芸香碱与噻吗心安滴眼液治疗青光眼时不同给药方式的治疗效果,总结两种药物联用的合理给药方式。方法本次课题研究采用动物实验法,此次研究于2016年1月~2016年5月开展,研究对象选用50只新西兰大耳白兔,将白兔随机分为5组,分别为毛果芸香碱组、噻吗心安组、常规同时给药组、毛果芸香碱＋噻吗心安组、噻吗心安组＋毛果芸香碱组,每组均有10只新西兰大耳白兔,按照不同给药方式进行给药,对比各组在第1次给药后10、20、30、40、60、90、120、150、180和240min后的眼压变化情况。结果各组不同给药方式给药后眼压随时间点变化而变化,毛果芸香碱组与噻吗心安组单一给药后眼压变化差异无统计学意义;毛果芸香碱＋噻吗心安组白兔眼压随时间的变化持续降低,相对于常规同时给药组、毛果芸香碱＋噻吗心安组以及噻吗心安组＋毛果芸香碱组眼压变化,眼压控制效果良好,对比差异有统计学意义（P〈0.05）。毛果芸香碱组、噻吗心安组、常规同时给药组、毛果芸香碱＋噻吗心安组以及噻吗心安组＋毛果芸香碱组各组不良反应差异无统计学意义。结论青光眼的治疗可联合应用毛果芸香碱与噻吗心安滴眼液进行治疗,毛果芸香碱＋噻吗心安相较于毛果芸香碱、噻吗心安单纯用药、常规给药几种给药方式,从持续降眼压时间上看,降眼压时间更长,不良反应较少,具有较高的治疗安全性,值得临床推广和应用。

Objective To analyze the therapeutic effect of combined administration of pilocarpine and timolol eye drops in the treatment of glaucoma,and to summarize the rational administration of the two drugs. Methods The study was conducted by animal experiment. The study was conducted from January 2016 to February 2016. Fifty New Zealand white rabbits were randomly divided into 5 groups： pilocarpine group,timolol group,conventional administration group,pilocarpine ＋ timolol group,timolol group and pilocarpine group. each group had 10 New Zealand white rabbits,according to different modes of administration,,the changes in intraocular pressure after 10,20,30,40,60,90,120,150,180 and 240 min after the first administration were compared. Results Intraocular pressure changes with time points after administration of different administration methods,There was no significant difference of IOP changes in pilocarpine group and timolol group single drug. pilocarpine ＋ timolol timolol group changes with time continuing to reduce intraocular pressure of rabbits,compared with the conventional dose group,pilocarpine ＋ timolol group and timolol pilocarpine ＋group alkali group of intraocular pressure,intraocular pressure and good control effect,the difference was statistically significant（ P 〈0. 05）. There was no significant difference between in the adverse reactions between pilocarpine group,timolol group,routine administration group,pilocarpine ＋ timolol group,timolol group and pilocarpine group. Conclusion The treatment of glaucoma can be treated with pilocarpine and timolol eye drops,pilocarpine ＋timolol compared with pilocarpine,timolol simple treatment,conventional administration of several modes of administration,from the continuous reduction of intraocular pressure time Point of view,lowering the intraocular pressure longer,fewer adverse reactions,with high therapeutic safety,worthy of clinical promotion and application.