低分子肝素联合心理干预在下肢骨折术后深静脉血栓预防中的应用分析

Application of low molecular weight heparin combined with psychological intervention in prevention of deep venous thrombosis after lower limb fracture surgery

目的研究分析低分子肝素联合心理干预在下肢骨折术后深静脉血栓预防中的临床应用。方法选取本院2013年1月~2016年12月收治的100例进行下肢骨折术患者作为本次研究过程中的研究对象,随机分为对照组和和实验组,每组50例。对照组患者进行常规的下肢物理加压预防下肢骨折术后的深静脉血栓,实验组患者进行低分子肝素联合心理干预来预防下肢骨折术后的深静脉血栓。比较分析实验组与对照组患者的凝血酶原时间以及血小板和活化部分凝血活酶时间指标。结果经过不同的治疗后,实验组患者的血小板指标为（189.23±36.23）×10~9/L,显著优于对照组（264.34±39.56）×10~9/L,差异具有统计学意义（P〈0.05）。治疗后,实验组患者的活化部分凝血活酶时间以及凝血酶原时间指标分别为（35.62±4.23）s和（16.12±2.19）s,显著优于对照组患者,差异具有统计学意义（P〈0.05）。结论低分子肝素联合心理干预在下肢骨折术后深静脉血栓预防中的应用,能够在很大程度上预防深静脉血栓的临床治疗效果,改善患者在手术后血液高凝状态,具有临床进一步推广和应用的意义。

Objective To study the clinical application of low molecular weight heparin combined with psychological intervention in the prevention of deep venous thrombosis after lower limb fracture surgery. Methods 100 patients with lower limb fracture treated in our hospital from January 2013 to December 2016 were selected as the research object in the course of the study,and randomly divided into control group and experimental group,with 50 cases in each group,. The patients in control group were treated with routine lower limb physical pressure to prevent deep venous thrombosis after lower limb fracture. The patients in the experimental group were treated with low molecular heparin combined with psychological intervention to prevent deep vein thrombosis after lower limb fracture. Comparative analysis of patients with prothrombin time and platelet and the experimental group and the control of activated partial thromboplastin time index. Results After different treatment,the platelet index of the experimental group was（ 189. 23 ± 36. 23） ×10~9/L,significantly better than that of the control group（ 264. 34 ± 39. 56） × 10~9/L,the difference was statistically significant（ P〈 0. 05）. After treatment,the patients in the experimental group the activated partial thromboplastin time and prothrombin time index respectively（ 35. 62 ± 4. 23） s and（ 16. 12 ± 2. 19） s,significantly better than the control group,the difference was statistically significant（ P〈 0. 05）. Conclusion low molecular weight heparin combined with application of psychological intervention in prevention of deep venous thrombosis after lower limb fracture surgery,can improve clinical curative effect on prevention of deep vein thrombosis in a large extent,improve blood hypercoagulable state of patients after surgery,with further clinical promotion and application significance.