右美托咪定对骨折患者静吸复合麻醉后苏醒期躁动的影响研究

Effect of dexmedetomidine on restlessness in recovery stage in patients with fracture undergoing combined intravenous inhalation anesthesia and operation

目的研究分析右美托咪定对骨折患者静吸复合麻醉后苏醒期躁动发生情况的影响。方法选取本院2015年2月~2016年8月静吸复合麻醉下行四肢骨折手术的患者80例随机分为对照组和实验组,每组40。手术开始前,实验组患者持续泵注右美托咪定（浓度4μg/mL）0.5ug/kg,时间15 min;对照组患者持续泵注等量生理盐水。分析比较2组患者苏醒时间、拔管时间、苏醒期躁动发生率和躁动评分、镇静评分情况等。结果实验组与对照组患者苏醒时间和拔管时间差异无统计学意义;实验组患者苏醒期躁动发生率和躁动评分均明显低于对照组,差异有统计学意义（P〈0.05）;实验组患者镇静评分高于对照组,差异有统计学意义（P〈0.05）。结论右美托咪定可降低骨折患者静吸复合麻醉后苏醒期躁动的发生率、减轻躁动程度,具有进一步推广和应用的临床意义。

Objective To investigate the effect of dexmedetomidine on restlessness in recovery stage in patients with limbs fracture undergoing combined intravenous inhalation anesthesia and operation. Methods Eighty patients with limbs fracture undergoing combined intravenous inhalation anesthesia and operation in our hospital were randomly divided into the control group and the dexmedetomidine group,40 cases in each group. Before operation,patients in the dexmedetomidine group were given dexmedetomidine 0. 5 μg/kg intravenously in 15 min; patients in the control group were given the same volume of 0. 9% saline solution. The recovery time,extubation time,the incidence of restlessness,agitation score and sedation score were compared between the two groups. Results The recovery time and extubation time had no significant difference between the two groups. The incidence of restlessness and agitation score in the dexmedetomidine group were significantly lower than those in the control group（ P 〈0. 05）,while the sedation score in the dexmedetomidine group was significantly higher than that in the control group（ P〈 0. 05）. Conclusion Dexmedetomidine can reduce the incidence of restlessness and the degree of restlessness in patients limbs fracture undergoing combined intravenous inhalation anesthesia and operation.