西格列汀联合二甲双胍治疗磺脲类药物失效老年糖尿病患者临床分析

Clinical analysis of serotretine combined with metformin in the treatment of senile diabetic patients with sulfonylurea failure

目的探讨西格列汀联合二甲双胍在磺脲类药物失效老年糖尿病患者治疗中的临床效果。方法将2013年1月~2016年12月在江山市人民医院进行治疗的60例磺脲类药物失效老年糖尿病患者作为研究对象,并将其按照随机数字法分成观察组30例与对照组30例,观察组患者给予西格列汀联合二甲双胍治疗,对照组患者给予优泌乐治疗,分别对2组患者的临床治疗效果、空腹血糖、餐后2h血糖、糖化血红蛋白、空腹C肽及餐后2 h C肽水平进行统计对比。结果观察组患者的临床治疗效果明显高于对照组;治疗前后2组患者的空腹血糖、餐后2h血糖、糖化血红蛋白、空腹C肽及餐后2 h C肽水平差异不明显,但2组患者治疗后的空腹血糖、餐后2 h血糖及糖化血红蛋白水平均明显低于治疗前,治疗后的空腹C肽及餐后2 h C肽水平均明显高于治疗前。结论西格列汀联合二甲双胍治疗磺脲类药物失效老年糖尿病患者的临床疗效与优泌乐同样值得肯定,且该联合用药使用更加方便,更适用于临床治疗,值得临床的推广及应用。

Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of sulfonylurea-deficient elderly patients with diabetes mellitus. Methods Sixty patients with diabetes mellitus were enrolled in our hospital from January 2013 to December 2016. The patients were divided into observation group（ 30 cases） and control group（ 30 cases） according to the random number method. The patients in the observation group were treated with sitagliptin and metformin. The patients in the control group were treated with gemcitabine,and the clinical treatment effect,fasting blood glucose,postprandial blood glucose,glycosylated hemoglobin,fasting C peptide and postprandial 2h C peptide Level of statistical comparison. Results The clinical effect of the observation group was significantly higher than that of the control group. Before and after treatment,the fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,fasting C peptide and postprandial 2h C peptide level were not significantly different After fasting blood glucose,2h postprandial blood glucose and glycosylated hemoglobin levels were significantly lower than before treatment,after treatment of fasting C peptide and postprandial 2h C peptide levels were significantly higher than before treatment. Conclusion The clinical efficacy of serotretine combined with metformin in the treatment of elderly patients with diabetes mellitus is similar to that of Yuxing,and the combination is more convenient and more suitable for clinical treatment. It is worthy to be popularized and applied in clinical practice.