摘要
目的:探讨不同抗菌药物在持续性血液置换治疗(CRRT)中剂量调整方案及药物代谢动力学的差异。方法:收集相关文献资料,归纳CRRT的患者常用抗生素的剂量调整方案,包括β-内酰胺类、头孢菌素类、碳青霉烯类、万古霉素等,总结各药物在CRRT中的药物代谢动力学特点。结果:对于合并感染的危重症患者,需要根据药物的药代动力学参数和CRRT的模式调整给药方案。由于不同药物的代谢通路和分子量大小的不同,药物推荐剂量也不同。结论:大多数抗菌药物在CRRT中均需要调整给药剂量,不合理的剂量方案可能带来治疗失败或发生不良反应。
Objective： To review the dose adjustment and pharmacokinetic differences of different antibiotics in continuous renal replacement therapy （CRRT）. Methods： Researches related the dose adjustment in CRRT patients were collected, including β- lactam penicillium, cephalosporins, carbapenems and vancomycin. Pharmacokinetic characteristics of medicine in CRRT were summarized. Results： It＇s necessary that dosage adjustment in CRRT should be done according to pharmacokinetic characteristics in critically ill patients with infection. Recommended dosages were different because of different metabolic pathways and variant molecular size. Conclusion： Adjustment the dosage of medication is needed in most antibiotics with CRRT, and unreasonable dosage regimens could result in ineffective treatment or drug adverse reactions.
出处
《临床药物治疗杂志》
2017年第4期11-14,共4页
Clinical Medication Journal
