摘要
目的:探讨戈舍瑞林治疗三苯氧胺(TAM)引起的绝经前激素受体阳性年轻乳腺癌患者卵巢囊肿的治疗效果。方法:36例服用三苯氧胺后出现卵巢囊肿(直径>5 cm)的激素受体阳性绝经前乳腺癌术后患者联用戈舍瑞林治疗为治疗组,42例服用三苯氧胺后出现卵巢囊肿(直径>5 cm)的激素受体阳性绝经前乳腺癌术后患者单作停药处理为观察组。结果:治疗组加用戈舍瑞林6个月后卵巢囊肿均消失,观察2年后无1例再出现卵巢囊肿;观察组停药后卵巢囊肿能缩小,观察2年后仅4例患者卵巢囊肿消失。两组比较,差异有统计学意义(χ~2=63.51,P=0.001)。结论:戈舍瑞林能有效治疗三苯氧胺引起的绝经前年轻乳腺癌患者卵巢囊肿。
Objective： To investigate the therapeutic effect of goserelin for ovarian cyst caused by tamoxifen （TAM） in young patients with premenopausal hormone receptor positive breast cancer. Methods： Ovarian cyst patients with premenopausal hormone receptor positive breast cancer were divided into treatment group （36 cases） and control group （42 cases）. The patients in the treatment group were treated with goserelin while those in the control group only stopped TAM. Results： In the treatment group, the ovarian cyst disappeared in all of the 36 cases within 6 months and the ovarian cyst did not recurred within two years. In the control group, the ovarian cyst reduced after stopping TAM and disappeared within two years in only four cases. There was significant difference between the treatment group and control group （P=0.001, χ2=63.51 ） . Conclusion： Goserelin is effective for ovarian cyst in young patients with premenopausal hormone receptor positive breast cancer.
出处
《临床药物治疗杂志》
2017年第4期65-67,共3页
Clinical Medication Journal
