血清唾液酸联合C反应蛋白测定在白血病化疗后粒缺期并感染中的临床意义

Clinical significance of simultaneous determination of derum C-reactive protein and sialic acid in patients with agranulocytosis with infection after leukemia chemotherapy

目的探讨血清唾液酸(SA)和C-反应蛋白(CRP)联合测定在急性白血病患者化疗后中性粒细胞缺乏早期感染的诊治中的临床意义。方法测定50名健康体检者及70例急性白血病患者确诊时、化疗后粒缺期并感染时、治疗后、感染控制后血清SA、CRP水平。结果急性白血病患者确诊时血清SA、CRP水平与健康对照组比较无明显差异(P>0.05),急性白血病患者化疗后中性粒细胞缺乏并感染时血清SA、CRP水平显著高于健康对照组(P<0.01)、急性白血病患者确诊时(P<0.01)、感染控制后(P<0.01)。结论联合测定血清SA、CRP有利于急性白血病化疗后中性粒细胞缺乏伴发热患者早期感染的诊断、治疗,感染控制后适时停用抗生素。

Objective： To investigate clinical significance of simultaneous determination of serum c-reactive Protein （CRP） and sialic acid （SA） in agranulocytosis with infection after leukemia chemotherapy. Methods：The level of serum CRP and SA in 50 healthy subjects and 70 patients with agranulocytosis with infection after leukemia chemotherapy were de- termined, Results：Compared with those of healthy persons, acute leukemia patients diagnosed had no apparent difference （P 〉 0.05 ）. Serum SA and CRP of agranulocytosis with infection after leukemia chemotherapy were obviously higher than those of healthy patients, acute leukemia patients when diagnosed（ P 〈 0.01 ）and those after infection control（ P 〈 0.01 ）. Conclusion：Simultaneous determination of serum CRP and SA is beneficial to the diagnosis ~and treatment of early infection in patients with agranulocytosis with infection after leukemia chemotherapy, and antibiotics are discontinued at the time of infection control.