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SSRI类抗抑郁剂在痴呆患者中的应用进展

Progress on SSRI in patients with dementia
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摘要 随着人口的老龄化,痴呆日益增多,至今全球大约有3500万患者,极大地增加了家庭和社会疾病负担,给患者和家庭带来痛苦.除智能下降外,60%~98%的患者在疾病过程中都会出现各种精神行为症状(Behavior and Psychological Symptoms of Dementia, BPSD),包括激越、淡漠、抑郁、幻觉妄想、睡眠障碍等,也是造成患者入院的主要原因[1].既往抗精神病药物常被用来处理BPSD,但由于会增加痴呆患者死亡率等安全性问题而受到限制[2].因此,近年来人们把目光转向了选择性5-羟色胺再摄取抑制剂(Selective Serotonin Reuptake Inhibitor,SSRI)抗抑郁剂.本文拟对近年来的有关SSRI在痴呆患者中的应用进展作一综述.
出处 《神经疾病与精神卫生》 2017年第5期363-365,共3页 Journal of Neuroscience and Mental Health
关键词 痴呆 抗抑郁药 SSRI 精神行为症状 认知功能 综述文献 Dementia Antidepressive agents Selective serotonin reuptake inhibitor Behaviorand psychological symptoms Cognitive function Reviews
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