老年男性高血压患者中左室肥厚与代谢指标相关性的研究

Correlation research of left ventricualr hypertrophy and metabolic index in elderly male patients with hypertension

目的:探讨老年男性高血压患者中,左室肥厚与同型半胱氨酸、血糖等代谢指标之间的关系。方法:收集119例患者,进行生化代谢指标、心脏彩色多普勒超声及24 h动态血压等检查,根据左室质量指数将患者分为左室肥厚组(n=46)和非左室肥厚组(n=73),分析两组的检查结果。结果:左室肥厚组的24 h平均收缩压、糖化血红蛋白、同型半胱氨酸均显著高于左室正常构型组(P<0.05),经多元线性逐步回归分析,24 h平均收缩压及同型半胱氨酸与左室质量指数相关。结论:老年高血压患者左室肥厚与多种因素有关,其中,高同型半胱氨酸对左室肥厚的影响独立于其他危险因素。

Objective： To explore the relationship between metabolic markers such as homocysteine,glucose and left ventricular hypertrophy（ LVH） in elderly hypertensive males. Methods： 119 patients undertook blood tests,echocardiography and 24 hour ambulatory blood pressure monitoring, then were divided into left ventricular hypertrophy group（ LVH）（ n = 46） and without left ventricular hypertrophy group（ NLVH）（ n = 73）. The general data,biochemical paremeters were analyzed. Results： In the LVH group,24 hour average systolic blood pressure（ 24 h SBP）,glycosylated hemoglobin and homocysteine were higher（ P〈0. 05）. Multiple linear stepwise regression analysis showed LVMI significantly correlated with 24 h SBP and homocysteine. Conculsion： LVH was associated with many factors in elderly patients. Hyperhomocysteine was an independent risk factor for LVH.