洛索洛芬钠不同给药时间对种植牙修复患者术后镇痛效果的影响

Effect of postoperative analgesia with Loxoprofen sodium in different times on dental implant patients

目的探讨洛索洛芬钠不同给药时间对种植牙患者术后镇痛效果的影响。方法选择400例行种植牙修复治疗的患者，根据随机数余数分组法将研究对象分成2组，一组为术前30min给予洛索洛芬钠片60mg，此组作为试验组。另一组为术后3h开始服用洛索洛芬钠片60mg，此组作为对照组。所有患者手术麻醉均采用复方盐酸阿替卡因注射液（碧兰麻）行局部浸润麻醉。术中使用Wong—Baker笑脸评估法、术后使用数字分级法（NRS）分别评估2组患者在术中及术后3、6、12、24h5个时间点的疼痛情况，并进行评分，以比较需行种植牙修复的患者分别在术前30min和术后3h首次口服洛索洛芬钠片（乐松）对镇痛效果的疗效。结果术中试验组无痛患者比率为99％（198／200），对照组无痛患者比率为97％（194／200），2组比较差异无统计学意义（x^2=2．041，P〉0．05）；试验组术后3、6、12h的无痛患者比率分别为60．5％（121／200）、79．0％（158／200）、83．5％（167／200），对照组分别为47．0％（94／200）、64．5％（129／200）、71．5％（143／200），2组比较差异均有统计学意义（x^2=14．255、15．447、11．165，P=0．007、0．004、0．011），而24h后试验组和对照组无痛患者比率分别为93．0％（186／200）、89．5％（179／200），镇痛效果差异无统计学意义（x^2=2．468，P〉0．05）。结论术前30min给予洛索洛芬钠片可以明显减轻患者术后出现疼痛的程度，并可以作为种植牙手术的常规镇痛方案。

Objective To investigate the effect of postoperative analgesia by using loxoprofen sodium on dental implant patients at different time points. Methods A total of 400 patients with dental implant treatment were divided into two groups by random number table method. The experimental group was firstly given loxoprofen sodium tablets （60 mg） in 30 minutes preoperatively, and the control group was firstly given on three hours after surgery （60 mg）. Local anesthesia was used to all dental implant surgery. Using the Wong- Baker Smile Assessment method in operation and Numerical Rating Scale （NRS） in postoperative respectively to assess pain level in surgery and 3 h, 6 h, 12 h and 24 h after surgery. Results The percentages of painless patients of the experimental group and the control group in operation were 99%（198/200） and 97%（194/200）, and there was no significant difference between them （A2=2.041, P 〉 0.05）; the percentages of painless patients of the experimental group at 3 h, 6 h, 12 h after surgery were 60.5%（121/200）, 79.0%（158/200）, 83.5%（167/ 200）, and the control group were 47.0%（94/200）, 64.5%（129/200）, 71.5%（143/200）, and there was significant difference between the control group and the experimental group （x^2=14.255,15.447, 11.165, P=0.007, 0.004, 0.011）; however, in the two groups, there was no significant difference at 24 h after surgery, the experimental group was 93.0% （186/200）, the control group was 89.5% （179/200）（x^2.468, P〉 0.05）. Conclusions Preoperative administration with loxoprofen sodium tablets can significantly reduce the risk of postoperative pain, and could be used as a conventional implant surgery analgesic program.