高敏C反应蛋白与老年冠心病患者冠脉侧支循环的相关性

The Relationship between High Sensitive C-reactive Protein of the Elderly Patients with Coronary Heart Disease and Coronary Collateral Circulation

目的探讨老年冠心病患者血清中高敏C反应蛋白(hs-CRP)浓度与冠状动脉侧支循环(CCC)的关系。方法选取2015年10月~2016年10月期间于潍坊市人民医院心内科接受经皮冠状动脉介入治疗的老年(>60岁)冠心病患者128例,测定其血清hs-CRP浓度;采用Rentrop方法对CCC进行分级(0~3级),分为CCC不良组(0~1级)和CCC良好组(2~3级),然后对比两组之间hs-CRP浓度。结果 128例患者中CCC不良42例,CCC良好86例;CCC不良组血清hs-CRP浓度高于CCC良好组(P<0.05);采用Spearman相关分析结果示:血清hs-CRP浓度与CCC分级呈负相关(r=-0.716,P<0.01)。结论在老年冠心病患者中,CCC不良者的血清hs-CRP浓度明显高于CCC良好者,提示高血清hs-CRP可能是冠脉侧支形成的一个不利因素。

Objective To investigate the relationship between high sensitive C-reactive protein（hs-CRP） of the elderly patients with coronary heart disease（CHD） and coronary collateral circulation（CCC）.Methods Enrolled 128 stable elderly coronary artery disease patients（age 60 years） who underwent percutaneous coronary intervention（PCI） of cardiovascular department in weifang people＇s hospital from October 2015 to October 2016.The patients were divided into two groups,according to their Rentrop scores：poorly developed CCC group（Rentrop 0 and 1） and well-developed CCC group（Rentrop 2 and 3）.hs-CRP and other biochemical markers were also measured.Results In the 128 elderly patients with CHD,42 patients＇ CCC were well-developed,and 86 patients＇ were poorly developed.Compared to the well-developed CCC group,the hs-CRP was higher in patients with poorly developed CCC（P〈0.05）.On Spearman correlation analysis,hs-CRP（r=-0.716,P〈0.01） had negative relation with CCC.Conclusion Compared to the well-developed CCC group,the hs-CRP is higher in patients with poorly developed CCC in the elderly patients with CHD.It reveal that hs-CRP may be a negative factor of CCC.