他克莫司软膏联合二氧化碳点阵激光治疗白癜风临床观察

The Clinical Observation of Combined Tacrolimus Ointment and CO_2 Fractional Laser for the Treatment of Vitiligo

目的评价外用他克莫司软膏联合二氧化碳点阵激光治疗白癜风临床疗效。方法患者101例,每例患者选择两处相近或对称部位的皮损,随机分为对照组和观察组,对照组皮损仅外用0.1%他克莫司软膏,2次/d,观察组外用他克莫司软膏联合二氧化碳点阵激光治疗,1次/月。治疗观察12周,治疗结束3d后评价疗效。结果对照组与观察组治疗起效时间分别为(6.48±3.13)周和(4.14±3.01)周,组间比较差异有统计学意义(P<0.05)。对照组与观察组总有效率分别为57.42%和79.21%,显效率分别为24.8%和39.6%,组间比较差异均有统计学意义(P<0.05)。所有患者在治疗过程中均未出现严重不良反应。结论他克莫司软膏联合二氧化碳点阵激光治疗白癜风安全有效,疗效优于单用他克莫司软膏。

Objective To evaluate the clinical efficacy of Tacrolimus ointment combined with CO2 fractional laser in the treatment of vitiligo.Methods One hundred and one patients were included,two symmetrical or nearby target lesions of each patients were chosen and were randomly divide into control group and observation group.Both groups of lesions were given Tacrolimus ointment,2 times/day;in addition to that,the treatment group was given CO2 fractional laser,1 times/month.Treatment was observed for 12 weeks,and the efficacy was evaluated after 3 days of treatment.Results The onset time of the control group and the observation group were（6.48 ＋ 3.13） weeks and（4.14 ＋ 3.01）weeks,the difference was statistically significant（P〈0.05）.The total effective rate of control group and observation group were 57.42% and 79.2% respectively,and the significant efficiency were 24.8% and 39.6%,the difference was statistically significant（P〈0.05）.No serious adverse reactions occurred in all patients during the treatment.Conclusion CO2 fractional laser combined with Tacrolimus Ointment in the treatment of vitiligo is effective and safe,the efficacy is better than the single use Tacrolimus Ointment.