中西医结合治疗肾病综合征临床疗效观察

Observation of the Clinical Effect of Integrative Chinese and Western Medicine in treating Nephrotic Syndrome

目的:分析中西医结合治疗方法治疗肾病综合征临床疗效观察,为以后的临床应用提供依据。方法:收集2014年9月至2016年9月肾病综合征的110患者,按照随机分组的原则,分成对照组和观察组,各30例,对照组采用西药治疗,观察组采用中西医结合治疗。对比2组患者治疗前后肾功能、炎性反应因子水平的变化,以及临床疗效、不良反应和复发率。结果:治疗后2组患者肾功能、炎性反应因子均有不同程度的改善,但是观察组优于对照组,2组差异有统计学意义(P<0.05)。观察组患者总有效率为89.09%显著高于对照组64.45%,差异有统计学意义(χ~2=8.75,P<0.05)。观察组不良反应发生率为23.64%,对照组为18.18%,但是差异无统计学意义(χ~2=0.50,P>0.05)。观察组总复发率为12.73%显著低于对照组23.64%(χ~2=4.45,P<0.05)。结论:中西医结合治疗肾病综合征,可以提高肾病综合征的总有效率,减少药物作用的不良反应率,提高肾功能,降低炎性反应,有待在临床中进一步推广应用。

Objective：To observe the clinical effect of integrative Chinese and western medicine in the treatment of nephrotic syndrome,and provide basis for future clinical application.Methods：A total of 110 cases of patients with nephrotic syndrome during September 2014 to September 2015 admitted in our hospital were collected and randomly divided into control group and observation group,with 30 cases in each group.Patients in the control group were treated with western medicine,while patients in the observation group were treated with integrative Chinese and western medicine.The changes of kidney function and inflammatory factor of patients in two groups before and after treatment were compared,as well as clinical curative effect,adverse reaction and recurrence rate.Results：After treatment,the kidney function and inflammatory factor of two groups were all improved in different degrees,but the performance of the observation group was better than that of the control group,and the differences were statistically significant （P〈0.05）.The total effective rate in the observation group was 89.09%,which was higher than 64.45% in control group with significant difference （x2=8.75,P〈0.05）.The incidence rate of adverse reactions in the observation group was 23.64%,while that of the control group was 18.18%,but there was no statistically significant difference （x2=0.50,P〉0.05）.The overall recurrence rate in observation group was 12.73%,which was significantly lower than 23.64% in control group （x2=4.45,P〈0.05）.Conclusion：Integrative Chinese and western medicine can improve the total effective rate of nephrotic syndrome,reduce the adverse reaction rate of drugs and the incidence of inflammatory response,as well as improve the renal function,therefore,is worth of further popularization and application in clinical practice.