健脾生血片与多糖铁复合物胶囊治疗妊娠期缺铁性贫血的临床对比研究

Clinical Efficacy Comparative Study of Jianpi Shengxue Tablet and Iron Polysaccharide Complex Capsules in Gestational Iron Deficiency Anemia

目的:对比观察健脾生血片和多糖铁复合物胶囊治疗妊娠期缺铁性贫血的临床疗效,为临床治疗IDA提供依据。方法:将200例缺铁性贫血的孕妇随机分为对照组(多糖铁复合物胶囊组)和观察组(健脾生血片组)。对照组100例,给予多糖铁复合物胶囊治疗;观察组100例,给予健脾生血片口服治疗。2组患者均于连续治疗1个月,2个月,3个月后,按贫血严重程度,分别分两层观察患者的红细胞计数(RBC)、血红蛋白(Hb)以及血清铁蛋白(SF)的含量变化,计算临床疗效,记录不良反应。结果:2组治疗3个月后RBC、Hb和SFI均显著改善(P<0.05),且观察组起效更快,有效率更高,指标在治疗1、2及3个月后均优于对照组(P<0.05);治疗3个月后观察组临床总有效率更高(P<0.05)。分层统计结果:1)对于中重度贫血患者,2组治疗后红细胞、血红蛋白和血清铁蛋白均有显著改善(P<0.05),且观察组起效更快,2组临床疗效有统计学意义(P<0.05),观察组更优;2)对于轻度贫血患者,治疗后红细胞、血红蛋白和血清铁蛋白均有显著改善(P<0.05)且观察组起效更快,2组临床疗效有统计学意义(P<0.05),观察组更优。观察组不良反应少于对照组但无统计学意义(P>0.05)。结论:健脾生血片治疗妊娠期贫血起效快、有效率高,不良反应少,值得临床推广应用。

Objective：To compare the clinical efficacy of Jianpi Shengxue tablet and iron polysaccharide complex capsules in the treatment of gestational iron deficiency anemia,and provide scientific basis for the treatment of gestational iron deficiency anemia.Methods：A total of 200 gestational iron deficiency anemia patients treated in our hospital were selected and divided into control group （group of iron polysaccharide complex capsules） and observation group （group of Jianpi Shengxue tablet） with 100 cases in each.Patients in the control group were given iron polysaccharide complex capsules,while patients in the observation group were given Jianpi Shengxue tablet.Changes of patients′ RBC,Hb and SF were observed after continuous treatment for one month,two months and three months according to the severity of anemia.Besides,clinical efficacy and adverse reactions were recorded.Results：After three months of treatment,RBC,Hb and SF in two groups were all significantly improved （P〈0.05）,in addition,the effective rate was higher and the curative effect was faster in the observation group.Indicators of observation group after treatment for one month,two months and three months were superior than those of control group （P〈0.05）;After 3 months,the clinical total effective rate in observation group was higher than that of control group （P〈0.05）.The results of hierarchical statistical：① In patients with moderate to severe anemia,the RBC,Hb and SF levels after treatment in two groups were higher than those before treatment （P〈0.05）,and the effect in observation group was faster （P〈0.05）.The curative effect in observation group was significantly better than that of control group （P〈0.05）.In patients with mild anemia,the RBC,Hb,SF levels after treatment were significantly improved （P〈0.05）,and the effect in observation group was faster.The curative effect in observation group was significantly better than that of control group （P〈0.05）.The adverse effects in observation group were less than control group without statistically difference.Conclusion：There is a significant and overt curative effect of Jianpi Shengxue tablet in treating gestational iron deficiency anemia,while with little adverse reactions,so it is worthy of clinical application.