纳米材料体外细胞毒性研究现状与展望

Research Situation and Prospects on in-Vitro Cytotoxicity of Nanomaterials

纳米科学是上个世纪80年代末发展起来的新兴学科,是21世纪最有前途的新科学技术之一。随着纳米材料应用的日益广泛,其所带来的健康风险也越来越大,对其生物安全性的研究也刻不容缓。文章就纳米材料的毒性影响因素,对细胞造成的毒性效应机制及其体外细胞毒性的评价方法进行详细阐述,并综述了近几年来关于纳米材料毒性研究的最新进展及对纳米技术安全性评估进行了系统的讨论。

Nanoscience emerged in the last 1980 s and is developed as one of the most promising new science and technology in the 21st century.With the increasing widespread application of nanomaterials,their health risk has been greatly increased and researches on its biological safety are imperatively needed.In this paper,the toxic influential factors,the cytotoxicity mechanism of nanomaterials and the evaluation methods on cytotoxicity of nanomaterials in vitro were elucidated in detail.Simultaneously,the latest developments on the toxicity of nanomaterials and the security assessment of nano technologies were also systematically discussed.