祛瘀接骨饮对骨折愈合过程中钙磷指标的影响

The Effect of Quyu Jiegu Decoction on Bone Calcium-phosphorus Index During the Healing Process of Bone Fracture

目的:通过观察自拟中药方剂祛瘀接骨饮,对骨折患者在骨折愈合过程中,不同时期钙、磷及钙磷乘积含量的变化以及DR摄片的骨痂形成情况,从而证实中药方剂祛瘀接骨饮对骨折患者的早期消肿、止痛和愈合有促进作用。方法:肱骨干闭合性骨折病例168例,随机分为2组,对照组86例,采用西医治疗方法,不予药物干预治疗,治疗组82例加服祛瘀接骨饮,对2组患者分别于骨折后第1、2、3、4周静脉采血,行血清钙、磷、钙磷乘积含量测定,观察祛瘀接骨饮对骨折愈合过程的影响。结果:82例加服祛瘀接骨饮的治疗组患者,在骨折愈合过程中较单纯采用西医治疗的86例对照组患者,缩短了骨折愈合时间;治疗组血钙含量,在骨折后1周明显升高(P<0.01);而后的2、3、4周血钙均逐渐下降(P<0.01或P<0.05);与此相反的是,治疗组血磷含量,在骨折后1周下降(P>0.05);而后的2、3、4周血磷均逐渐升高(P<0.01或P>0.05);同对照组比较,治疗组血钙下降和血磷升高均更明显(P<0.05或P<0.01)。结论:祛瘀接骨饮能够降低血钙、升高血磷和钙磷乘积,从而说明祛瘀接骨饮缩短骨折愈合时间,大大提高了骨折患者的早期治愈率。

Objective： By observing the effect of self-made traditional Chinese medicine Quyu Jiegu decoction on the calcium-phos- phorus index among patients in bone fracture healing Process, as well as its effect on callus formation and calcium-phosphorus product to detect the curative effect of the decoction in relieving early swelling, pain and accelerating healing. Methods ： A total of 168 cases of closed humeral shaft fractures were randomly assigned to two groups, namely, control group （86 cases） , treated with western medicine with our drug intervention, and treatment group （82 eases） treated with Quyu Jiegu decoction. To detect the content of calcium, phosphors, and calcium-phosophers product respectively after 1, 2, 3, 4 weeks by taking peripheral vain blood, thus investigating the effect of Quyu Jiegn decoction. Results： The healing duration of the treatment group is shorter than that of the control group. After 1 week, the calcium content in the treatment group increased significantly （P 〈 0. 01 ）, and in 2, 3 and 4 weeks, serum calcium decreased gradually （ P 〈 0. 01 or P 〈 0.05）. On the other hand, the treatment group blood phos- phorus content after 1 week decreased （ P 〉 0. 05 ） ; and 2, 3 and 4 weeks were increased gradually （ P 〈 0. 01 or P 〉 0. 05 ）. Within the control group, the treatment group, serum calcium decreased and serum phosphorus were increased significantly （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion： Quyu Jiegu decoction can decrease the level of serum calcium and increased serum phosphorus and calcium-phosphorus product. Also, it can shorten the healing time, greatly improve the cure rate of fractures in early period.