中药复方抗氧化治疗阿尔茨海默病

Anti-oxidative Chinese Herbal Formulas in Treatment of Alzheimer's Disease

阿尔茨海默病(Alzheimer's Disease,AD)是一种常见的神经退行性疾病,β-淀粉样蛋白(β-amyloid,Aβ)诱导的氧化应激是其重要的发病因素。Aβ通过与细胞表面的晚期糖基化终产物受体(Receptor for Advanced Glycationendproducts,RAGE)结合诱发氧化应激损伤;也可以通过Aβ的第35位氨基酸残基蛋氨酸(Met-35)诱导氧化应激损伤;还可以插入脂质双分子层,催化自由基的产生,导致氧化应激损伤,参与AD发病。地黄饮子、左归丸、黄连解毒汤等经典方,补肾益智汤、黄精地龙方、还脑益聪方等当代验方可抑制自由基的生成,保护神经元免受氧化应激的伤害,从而防治AD。

Alzheimer＇s disease （AD） is a common neurodegenerative disease and its pathogenesis is related to oxidative stress in- duced by β-amyloid （ Aβ ）. Aβ induces oxidative stress through three pathways, namely 1 ） binding to the receptor of advanced gly- cation end products （RAGE） on cell surface; 2） inducing oxidative stress by the 35th methionine residue （Met-35） of Aβ; 3 ） catalyzing the synthesis of free radical by inserting into lipid bilayer. Some classic herbal formulas, such as Di-Huang-Yin-Zi De- coction,Zuo-Gui Pill and Huang-Lian-Jie-Du Decoction,as well as contemporary empirical herbal formulas including Bu-Shen-Yi- Zhi Decoction, Huang-Jing-Di-Long Decoction and Huan-Nao-Yi-Cong Decoction, can inhibit generation of free radical, protect neu- rons from oxidative stress damage and thus contribute to AD prevention and treatment.