中药外敷法对轻中度膝关节骨性关节炎WOMAC评分和VAS评分的影响

Effect of External Application of Chinese Medicinal on Mild-to-moderate Osteoarthritis of Knee WOMAC and VAS Scores

目的:采用WOMAC评分和VAS评分,评估中药外敷疗法治疗轻中度膝关节骨性关节炎的疗效及安全性。方法:选取72例轻中度膝关节骨性关节炎的患者,采用随机数字表分为中药外敷组(n=36)与口服西药组(n=36)。中药外敷组,选取阿是穴,每次外敷48 h,隔1 d或2 d再次换药,治疗2次/周;口服西药组给予硫酸氨基葡萄糖胶囊,2粒/次,3次/d。2组患者均治疗4周。治疗前、治疗后2周、治疗后1个月采用WOMAIC评分表及VAS疼痛量表评价疗效。治疗后3个月测量VAS疼痛量表以评价远期疗效。结果:中药外敷组脱落2例,予以剔除。口服药物组无脱落。2组患者治疗前、治疗后2周、治疗后1个月、治疗后3个月VAS评分进行比较,P<0.05,差异均有统计学意义。2组患者治疗前、治疗后2周、治疗后1个月WOMAC评分进行比较,P<0.05,差异均有统计学意义。治疗两周后,中药外敷组VAS评分与口服西药组进行比较,P<0.05,差异有统计学意义;中药外敷组WOMAC评分与口服西药组进行比较,P>0.05,差异无统计学意义。治疗1个月后,中药外敷组VAS评分、WOMAC评分与口服西药组进行比较,P>0.05,差异无统计学意义。治疗期间,中药外敷组出现了1例轻度过敏患者,不良反应率占3%;口服西药组出现了3例胃肠道反应患者,不良反应率占8%。结论:中药外敷疗法短期止痛效果好,是一种安全性高,有一定远期疗效的治疗方法。

Objective：To evaluate the therapy efficacy and safety of external application of Chinese medicinal in treatment of mild-to-moderate knee joint osteoarthritis by the WOMAC and VAS scores.Methods：A total of 72 mild-to-moderate knee joint osteoarthritis patients were selected and randomly divided to two groups：external application of Chinese medicinal group（n=36） and the western medicine group（n=36）.External application of Chinese medicinal group was given external application of Chinese medicinal on their ashi point, 48 hours each time, the medicinal was changed every 2 or 3 days, twice per week;the western medicine group patients took glucosamine sulfate capsules orally every day, two pieces each time and three times each day.The two groups were treated for four weeks.The WOMAIC and the VAS scores were used to evaluate the efficacy before treatment, 2 weeks after treatment and 1 month after treatment.The VAS pain score was used to assess efficacy of 3 months after treatment as the long-term outcome.Results：During the treatment, 2 cases fell off in external application of Chinese medicinal group.No one fell off in oral drug group.There were significant differences （P〈0.05） in VAS pain score in both groups compared with the statistics before the treatment, 2 weeks, 1 months and 3 months after the treatment.There were also significant differences （P〈0.05） in WOMAC scores in both two groups compared with the statistics before the treatment, 2 weeks and 1 month after treatment.There were significant differences in VAS pain score （P〈0.05） after two weeks＆#39; treatment between the two groups, but no differences in WOMAC scores.No significant differences were shown in VAS pain score and WOMAC scores after 1 month＆#39;s treatment in two groups.One case in external application Chinese medicinal group showed mild allergy （adverse effect rates=3%）.Three cases experienced gastrointestinal tract reaction in western medicine （adverse effect rates=8%）.Conclusion：External application of Chinese medicinal is a safe and effective treatment with certain long-term effect.