消糜膏对宫颈炎患者的临床疗效及对宫颈局部EGF、IL-1β、TNF-α表达的影响

Clinical Effect of Xiaomi Ointment on Patients with Cervicitis and Its Effects on cervical local EGF,IL-1 beta,TNF-alpha expression

目的:探讨消糜膏对宫颈炎患者的临床疗效及对宫颈局部人表皮生长因子(EGF)、白细胞介素1β(IL-1β)及肿瘤坏死因子α(TNF-α)表达的影响。方法:选取2015年6月至2016年3月我院妇科收治的宫颈炎患者64例,随机分为观察组和对照组,各32例。对照组接受微波治疗,观察组采用消糜膏治疗。统计2组临床有效率;检测并比较治疗前后2组患者宫颈局部IL-1β,TNF-α及EGF等的水平变化;统计2组患者治疗后阴道排液时间、结痂出血时间、愈合时间及排血量和排液量。结果:2组临床有效率比较,差异无统计学意义(P>0.05);与治疗前比较,2组患者宫颈局部IL-1β,TNF-α水平显著降低,EGF水平显著升高(P<0.05)。观察组宫颈局部IL-1β,TNF-α水平显著低于对照组(P<0.01);而EGF水平显著高于对照组(P<0.01)。结论:消糜膏可通过升高EGF水平,降低IL-1β、TNF-α水平达到消除宫颈炎的目的,与微波治疗宫颈炎的临床疗效相当,但其可有效缩短宫颈愈合时间,减少治疗中出血量和排液量。

Objective：To investigate the clinical effect of Xiaomi ointment on patients with cervicitis and its effects on cervical local human epidermal growth factor （EGF）, interleukin 1 beta （IL-1 beta） and tumor necrosis factor alpha （TNF-alpha） expression.Methods：In total, 64 patients with cervicitis in our hospital from June 2015 to March 2016 were selected and randomly divided into an experimental group and a control group, with 32 cases in each group.Patients in the control group received microwave treatment, while patients in the experimental group were treated with Xiaomi ointment.The clinical efficacy rate of the two groups were collected, and the changes of cervical local IL-1 beta, TNF-alpha and EGF levels in the two groups were recorded and compared.Patients＇ vaginal discharge time, scabby bleeding time, healing time, output and drainage volume in the two groups were also observed.Results：There was no significant difference in clinical efficacy between the two groups （P〉0.05）.Compared with the data before treatment, cervical local IL-1β and TNF-α levels in two groups both decreased significantly, while EGF levels increased （P〈0.05） significantly.Cervical IL-1β and TNF-α levels in the experimental group were significantly lower than those in the control group （P〈0.01）, while its EGF levels were significantly higher than those of the control（P〈0.01）.Conclusion：Xiaomi ointment can eliminate the cervicitis by increasing EGF levels and decreasing levels of IL-1β and TNF-α.Its efficacy is similar to that of microwave treatment, but it can effectively shorten the healing time of cervix and reduce the amount of bleeding and drainage in the treatment.