益气泻肺冲剂治疗慢性心力衰竭的临床观察

Clinical Observation on Yiqi Xiefei Granule in Treating Chronic Heart Failure

目的:观察比较益气泻肺冲剂与西药治疗慢性心力衰竭(CHF)的临床疗效。方法:选取2011年1月至2013年12月期间在北京市昌平区中医医院心血管病科确诊为慢性心力衰竭(CHF)的患者70例,随机分为对照组和观察组,每组35例。对照组按西医常规治疗方案进行治疗;观察组则在对照组基础上,根据辨证加用中药益气泻肺冲剂加减进行治疗。观察治疗前后心力衰竭患者的临床症状、体征、心肺运动试验(CPET)后指标、左室射血分数(LVEF)、左室舒张末径值(LVED)及血浆NT-pro BNP水平。结果:治疗后,观察组症状积分及体征积分均低于对照组,其差异有统计学意义(P<0.05);2组患者治疗后LVEF上升、LVED下降、血浆NT-pro BNP水平下降,观察组LVEF上升、NT-pro BNP指标下降较对照组明显(P<0.05);观察组CPET试验结果(峰值氧耗量、无氧阈)提高,较对照组明显(P<0.05)。结论:益气泻肺冲剂能够有效改善慢性心力衰竭(CHF)患者的证候、临床症状,改善患者心功能。

Objective： To observe the clinical efficacy of Yiqi Xiefei granule in the treatment of chronic heart failure （CHF）. Methods：Seventy patients with chronic heart failure （CHF） were randomly divided into control group （n =35 ） and treatment group （ n = 35 ）. The control group was treated with routine western medicine. The treatment group was treated with traditional Chi- nese medicine Yiqi Xiefei granule on the basis of routine western treatment. Left ventricular ejection fraction （LVEF） , left ventricular end diastolic diameter （LVED） and NT-proBNP were measured before and after treatment. Clinical symptoms, signs, car- diopulmonary exercise test （CPET） results were recorded. Results：After treatment, symptom scores and signs scores of the treat- ment group were significantly lower than those of the control group （ P 〈 0. 05 ）. After treatment, LVEF increased, LVED de- creased, NT-proBNP decreased, LVEF increased, NT-proBNP in both groups （P 〈 0. 05）. After treatment, CPET （peak oxygen consumption, anaerobic threshold） in the treatment group were significantly higher than those in the control group （ P 〈 0. 05 ）. Conclusion：Yiqi Xiefei granule can effectively improve the symptoms of patients with chronic heart failure （CHF） as well as cardiac function.