花藤子颗粒联合枸地氯雷他定治疗变应性鼻炎的临床研究

Clinical Study on Huatengzi Granules Plus Desloratadine Citrate Disodium in the Treatment of Allergic Rhinitis

目的:观察花藤子颗粒联合枸地氯雷他定治疗变应性鼻炎的临床疗效。方法:选取2015年9月至2016年9月江苏省中医院耳鼻咽喉科门诊收治的变应性鼻炎患者80例按随机数字表法随机分为观察组和对照组,每组40例。对照组口服枸地氯雷他定,观察组在对照组基础上加用花藤子颗粒,2组患者均服药4周,采用RQLQ评分、症状体征积分、视觉模拟量表(VAS)评分和总有效率对临床疗效进行评价,并统计不良反应。结果:2组各有39例患者完成试验。治疗后2组RQLQ、VAS、症状体征积分与治疗前比较均显著降低(P<0.05)。观察组在鼻痒、流清涕积分及总有效率方面与对照组比较无统计学意义(P>0.05),在改善RQLQ评分、喷嚏、鼻塞、症状总评分及体征积分方面优于对照组(P<0.05)。观察组出现腹泻1例,余无不良反应。结论:花藤子颗粒联合枸地氯雷他定治疗变应性鼻炎具有良好的临床疗效及安全性,值得推广。

Objective：To observe the clinical effect of Huatengzi Granules plus desloratadine citrate disodium on allergic rhinitis. Methods： A total of 80 patients with allergic rhinitis in Jiangsu Provincial Hospital of Traditional Chinese Medicine from Septem- ber, 2015 to September, 2016 were randomly divided into treatment group （n = 40） and control group （n = 40） by the random number table. The control group received desloratadine citrate disodinm, and the treatment group was treated with Huatengzi Gran- ules plus desloratadine citrate disodium. Both groups were treated for 4 weeks. After treatment, the VAS scores, RQLQ scores, symptom and syndrome scores and total effective rates were measured to evaluate the clinical efficacy, and the total number of cases of adverse reactions was statistically analyzed. Results：A total of 39 patients in each group finished the trial, There were statistical differences between the two groups＇ VAS scores, RQLQ scores, and symptom and syndrome scores before and after treatment （ P 〈 0. 05）. After treatment, there were no statistical differences in nasal itching, watery nasal discharge and the total effective rates （P 〉 0. 05）. But there were statistical differences in the aspects of VAS scores, RQLQ scores, sneezing, nasal congestion, and symptom and syndrome scores between the two groups （ P 〈 0.05 ）. There was no case of adverse reaction except for one patient in the treatment group with mild diarrhea. Conclusion ： Huatengzi Granules plus desloratadine citrate disodium has good clinical effica- cy and safety for the treatment of allergic rhinitis.