黄芪注射液对慢性心力衰竭病人生存质量及N-末端脑钠肽前体的影响

Effect of astragalus injection on the quality of life and N-terminal pro brain natriuretic peptide in patients with chronic heart failure

目的观察黄芪注射液对慢性心力衰竭病人的生存质量及N-末端脑钠肽前体的影响。方法将60例慢性心力衰竭病人随机分为治疗组(30例)与对照组(30例)。2组均给予西医指南规范治疗,治疗组在西医指南规范治疗基础上同时静点黄芪注射液,观察2组病人治疗前后6 min步行距离(6MWD)及NT-pro BNP水平的变化。结果治疗2周后,2组病人6 min步行距离均明显增加(P<0.01),但治疗组优于对照组(P<0.05);2组病人治疗后NT-pro BNP均明显下降,治疗组略优于对照组(P<0.05)。结论黄芪注射液联合西医指南规范治疗慢性心力衰竭可改善病人生存质量,降低NT-pro BNP水平。

Objective To observe the effect of astragalus injection on the quality of life and N-terminal pro brain natriuretic peptide（NT-pro BNP） in patients with chronic heart failure. Methods A total of 60 patients with chronic heart failure were randomly divided into treatment group（n=30） and control group（n=30） according to age, sex and stage. The two groups were given western medicine standardized treatment. The treatment group was treated with intravenous injection of astragalus injection on the basis of western medicine standardized treatment. To observe patients the changes of 6 minutes walking distance（6MWD） and NT-pro BNP levels before and after treatment in the two groups. Results After 2 weeks of treatment, the walking distance of the patients in the two groups increased significantly（P〈0.01）, but the treatment group was better than the control group（P〈0.05）. Two groups of patients after treatment NT-pro BNP were significantly decreased, the treatment group was slightly better than the control group（P〈0.05）. Conclusion Astragalus injection combined with western medicine standardized treatment for the treatment of chronic heart failure can improve the quality of life with reduced NT-pro BNP levels.