大兴安岭地区世居汉族人群动脉血氧饱和度(SaO_2)与高血压迟发性相关

Association of oxygen saturation of arterial hemoglobin with late-onset hypertension in Chinese Han population resided in the Daxinganling area

目的揭示世居东北大兴安岭地区人的动脉血氧饱和度(SaO_2)与高血压迟发性的关联。方法样本收集用方便取样法;研究对象为大兴安岭地区世居汉族人群;通过问卷调查、常规体格检查和生化指标测定获取人口学、人体学及临床资料;使用指夹式脉搏血氧仪测定SaO_2。结果该人群SaO_2平均值为97.71%±6.14%,变化范围在88%~100%;SaO_2与性别、BMI和年龄相关(P<0.01),SaO_2随BMI增加和年龄增长呈规律性下降;SaO_2随年龄增长而下降与高血压危险性随年龄增长而增加明显相关(P<0.05),40~50岁年龄段下降尤为明显(P<0.01);相反,在此年龄段高血压发生危险性急骤升高(P<0.01);SaO_2从97.85%降至97.41%较群体平均值仅降低0.3%,高血压患病风险性升高10倍多(P<0.001)。结论 SaO_2随年龄增长而降低可能是人类高血压发病的主要病因之一,可部分地解释原发性高血压迟发性的特点。

Objective To identify the association of oxygen saturation of arterial hemoglobin （ SaO2） with late-onset hypertension in the Chinese Han population located in the Daxinganling area. Methods A total participants were selected by convenience sampling methods from the Daxinganling area. All data were collected from each person by the questionnaire record of physical examinations as well as biochemical index measuring. SaO2 was noninvasively measured with finger pulse oxymetry, the reported SaO2 was the average of three readings taken 10 seconds apart. Results There were significant differences for SaO2 within the population of individuals, the mean SaO2 values was 97.71%_＋6. 14%, with range from 88% to 100%. There was association of SaO2 with sex, BMI and age. SaO2 level declined with BMI and age increasing. Particularly, it was found that the risk increasing to hypertension was marked association with SaO2 rapid drop. During the period from 40-50 years of age, SaO2 declined from 97.85% to 97.64%, The risk to hypertension increased more than 10 times（P〈0. 001）. That implicated hypoxia mightinvolve in the etiology of hypertension. Conclusions The preliminary results demonstrated the rapid decline of SaO2 with lapse of age may be one of the major risk factors to hypertension, it may be helpful to explain late-onset hyper- tension to some extent at least.