2型自身免疫性胰腺炎的临床特点

Clinical characters of type 2 autoimmune pancreatitis

目的 1型自身免疫性胰腺炎(AIP)近年来逐渐为临床所关注,然而2型AIP在亚洲人群中较为罕见。本文对北京协和医院的2型AIP患者的临床特点及诊治经验进行了总结。方法该中心所有2001年1月至2016年12月间符合国际共识诊断标准的2型AIP住院患者被纳入研究。所有入选患者的临床数据、实验室结果和影像学特征均得到详细记录、核实、统计学计算和随诊。结果共有6例2型AIP患者被纳入研究。男女比例为2/1,发病平均年龄为38.4岁。67.7%(4/6)的患者合并溃疡性结肠炎。37.7%(2/6)的患者是无症状查体发现。3例患者通过病理确诊。50%(3/6)患者影像学表现为胰腺弥漫增大,50%(3/6)患者表现为胰腺肿物。结论中国的2型AIP患者临床表现与国外报道基本一致。

Objective The type 1 autoimmune pancreatitis is gradually being recognized, but the type 2 AlP is still very rare in Asia. This paper summarizes the clinical characters of type-2 AIP patients in Peking Union Medical College Hospital.Methods From January 2001 to December 2016 ,all type 2 AIP hospitalized patients who met the ICDC were included in the study. The clinical data, laboratory results and imaging features of all patients were recorded, verified and follow-up. Results Six patients with type 2 AlP were included in the study. The ratio of men and women was 2/1, with an average age of 38.4 years. 67.7% （4/6） patients have UC. 37.7% （2/6） of patients were asymptomatic. Three patients were diagnosed by pathology. 50% （3/6） of patients showed mass of pancreas, and 50% （3/6） of patients showed pancreatic enlargement. Conclusions The clinical manifestations of the type 2 AIP patients in Peking Union Medical College Hospital are the same as those in foreign countries.