高危型人乳头瘤病毒检测在子宫颈癌筛查中的临床应用效果研究

Clinical study on the effect of cervical cancer screening in high-risk human papillomavirus detection

目的:探讨人乳头瘤病毒及行为危险因素与子宫颈癌的临床关系。方法:通过分析2014年6月至2015年6月医院收治的203例HPV感染患者的临床资料,对患者临床资料进行整合,探讨HPV感染及相关行为危险因素及其同子宫颈癌的相关关系。结果:HPV感染并发宫颈癌患者中高危HPV患者占比显著高于低危HPV感染患者,比较差异有统计学意义(P<0.05);两组患者行为危险因素中吸烟、首次性行为年龄、性伴侣个数、性卫生意识、孕次和避孕方式相关因素指标存在显著差异,有统计学意义(P<0.05)。结论:高危型HPV感染是诱发子宫颈癌的高危因素,性行为及吸烟等行为危险因素同子宫颈癌发病有一定的相关性。

Objectives： To investigate the relationship between clinical and behavioral risk factors for hu-man papillomavirus（ HPV） and cervical cancer. Methods： The clinical data of 203 HPV-infected patients admitted to hospital from June 2013 to August 2015 was analyzed to explore the correlation between HPV infection and its behavioral risk factors and cervical cancer. Results： Among patients with cervical cancer complicated by HPV infection,the proportion of patients with high-risk HPV infection was significantly higher than the proportion of patients with low-risk HPV infection,with statistically significant difference（ P〈0. 05）. Differences in the behavioral risk factors between the two groups such as smoking,age of first sexual activity,number of sexual partners,sexual health awareness,pregnancies and contraception associated factors were statistically significant（ P〈0. 05）.Conclusion： The high-risk HPV infection is a risk factor of cervical cancer,and behavioral risk factors such as sex and smoking are also related to cervical cancer to a certain degree.