腹腔镜手术联合甲氨蝶呤治疗异位妊娠的疗效及对性生活质量的影响

Curative effect of laparoscopic surgery combined with methotrexate for the treatment of ectopic pregnancy and its influence on the quality of sex life

目的:探究与分析腹腔镜手术联合甲氨蝶呤治疗异位妊娠的疗效及对性生活质量的影响。方法:选取我院收治的90例异位妊娠患者,采取随机数字表法分为对照组与观察组,每组各45例,对照组给予腹腔镜手术联合术后口服米非司酮,观察组在对照组基础上于手术过程中采用30mg的甲氨蝶呤对病灶部位行局部注射,对比两组患者临床治愈率、血β-HCG降低至正常范围所需时间、输卵管再通率、随访1年内宫内妊娠率及性生活质量。结果:观察组与对照组相比临床治愈率、输卵管再通率、随访1年内宫内妊娠率均较高,血β-HCG降低至正常范围时间缩短,差异有统计学意义(P<0.05)。观察组与对照术组相比每周性生活频率增加,性唤起时间缩短,获得高潮时间延长,性生活满意度升高,差异有统计学意义(P<0.05)。结论:腹腔镜手术联合术前使用甲氨蝶呤治疗异位妊娠的临床疗效显著,促进改善了性生活质量,保留了生育功能,术后妊娠率更高。

Objectives： To probe into and analyze the curative effect of laparoscopic surgery combined methotrexate for the treatment of ectopic pregnancy and its influence on the quality of sex life. Methods： 90 patients with ectopic pregnancy treated in our hospital were selected and randomly divided into control group and observation group,45 cases in each group. The control group was given oral mifepristone after laparoscopic surgery,while the observation group was given local injections of 30 mg methotrexate during the operation on the basis of the control group. The clinical cure rate,time needed for blood β-HCG reducing to the normal range,reopening rate of fallopian tubes,the intrauterine pregnancy rate in 1-year follow-up and quality of sex life between the two groups were compared. Results： The clinical cure rate,reopening rate of fallopian tubes,intrauterine pregnancy rate within 1-year follow-up were higher in the observation group,and the time needed for blood β-HCG reducing to the normal range was shorter than those in the control group,with statistically significant difference（ P〈0. 05）. Compared with control group,the weekly frequency of sex increased,sexual arousal time shortened,time of orgasm prolonged and sexual satisfaction increased in the observation group,with statistically significant difference（ P〈0. 05）. Conclusion： Laparoscopic surgery combined preoperative use of methotrexate is of distinct effect in the treatment of ectopic pregnancy,which improves the quality of sexual life and retains the function of fertility,with higher postoperative pregnancy rate.