医用透明质酸钠凝胶结合不同治疗方法在预防人流术后宫腔粘连中的作用

The effect of medical sodium hyaluronic acid combined with different methods for prevention of intrauterine adhesion after induced abortion

目的:探讨患者人流术后宫腔注射透明质酸钠凝胶并联合口服短效避孕药物在预防术后宫腔粘连方面的临床效果。方法:选取2012年1月至2015年1月在我院进行人流手术且术程顺利的219例患者,随机分为三组。B组患者透明质酸钠凝胶2m L宫腔注射联合口服去氧孕烯炔雌醇,C组患者透明质酸钠凝胶2m L宫腔注射联合口服复方左炔诺孕酮,所有患者均常规口服抗生素及益母草颗粒。比较术后三组患者的宫腔积液及宫腔粘连情况。结果:A组有8例(12.9%)患者出现宫腔粘连,B组与C组均分别只有3例(3.85%)。与A组相比较,B组和C组的宫腔粘连率显著偏低(P<0.05)。但B组与C组之间的差异并不具有统计学意义(P>0.05)。结论:患者人流术后宫腔注射透明质酸钠凝胶并联合口服短效避孕药物可以有效降低术后宫腔粘连的发生率。

Objectives： To explore the effect of uterine cavity injection of medical sodium hyaluronic acid combined with oral short-acting contraceptives for prevention of intrauterine adhesion after induced abortion.Methods： 219 patients underwent induced abortion from January 2012 to January 2015 in our hospital were selected and divided into three groups. Patients in group B received uterine cavity injection of medical sodium hyaluronic acid and oral desogestrel and ethinylestradiol. Patients in group C received uterine cavity injection of medical sodium hyaluronic acid and oral compound levonorgestrel. All patients were given routine antibiotics and motherwort particle. The incidences of uterine cavity effusion and intrauterine adhesion were compared. Results： There were 8 patients（ 12. 9%） with intrauterine adhesion in group A,while 3 such cases（ 3. 85%） in group B and C respectively. The difference between group A and group B and C was significant（ P〈0. 05）,but the difference between group B and group C was not statistically significant（ P〉0. 05）. Conclusion： The postoperative injection of medical sodium hyaluronic acid combined with oral short-acting contraceptives can effectively prevent the occurrence of intrauterine adhesion.