酒精戒断性震颤谵妄患者的危险因素分析

The study of biochemical indicator changes of delirium tremens inpatients with alcohol dependence

目的:探讨酒精所致精神和行为障碍患者中出现震颤谵妄症状者血生化指标变化及危险因素的分析。方法:符合入组条件的使用酒精所致的精神和行为障碍男性患者78例,将伴有谵妄的戒断状态者设为研究组(37例),未出现谵妄状态者设为对照组(41例),对两组各项生化指标进行检测分析,并对出现震颤谵妄症状者相关影响因素进行分析。结果:震颤谵妄组与对照组在年龄、饮酒年限,每日饮酒的次数、伴有脑部器质性病变、有发热感染,以及谷氨酰转移酶、甘油三酯、肌酸激酶、乳酸脱氢酶、a-羟丁酸的水平显著高于对照组,血钾水平显著低于对照组,差异均具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,饮酒年限长、乳酸脱氢酶水平显著增高及血钾水平显著降低时出现震颤谵妄的危险性增大。结论:通过监测血生化指标变化及其他相关危险因素,来识别酒精所致震颤谵妄的高危人群,进而进行早期干预,对于防治酒精性震颤谵妄症状的出现,减少震颤谵妄发作引起的损伤具有重要的临床意义。

Objective：To study the biochemical indicator changes and the risk factors for delirium tremens（DT）inpatients with alcohol dependence. Methods：37 male inpatients with DT were assigned to research group and 41 ones without to control group. All biochemical indicators of both groups and the risk factors for DT were analyzed. Results：The age, the alcohol drinking years, drinking frequency, with cranial disease, have a fever, and γ‐glutamyltranspeptidase（GGT）,the triglyceride（TG）,creatine kinase（CK）,lactate dehydrogenase（LDH）, hydroxybutyric acid（HBDH） level were significantly higher and K^＋ lower in research group than control group. Multivariate conditional logistic regression analyses displayed that DT risk increased when the alcohol drinking years, lactate dehydrogenase（LDH） and K＋ level were significantly differed. Conclusion： Monitoring related blood biochemical indicators and the risk factors has important guiding significance for preventing DT development of alcohol dependence patients.