血清抵抗素与胃癌恶病质的关系

Relationship between serum resistin and gastric cancer-associated cachexia

目的观察血清抵抗素与胃癌及胃癌恶病质的关系,并初步探讨胃癌恶病质中抵抗素与白介素-6相关性。方法选取胃癌并恶病质患者23例为胃癌恶病质组,胃癌患者23例为胃癌组、健康成人23例为对照组。记录患者性别、年龄、BMI及肿瘤分期。采用ELISA法测定血清抵抗素和白介素-6水平(IL-6)。结果Ⅲ、Ⅳ期胃癌较Ⅰ、Ⅱ期胃癌更易发生恶病质(P<0.05),与健康成人相比血清抵抗素、白介素-6在胃癌及胃癌恶病质中升高(P<0.05)。血清抵抗素水平随着胃癌病理分期的增加有逐渐升高趋势(P<0.05)。胃癌恶病质组血清白介素-6水平与血清抵抗素水平显著正相关(r=0.512,P=0.012)。结论血清抵抗素水平随着胃癌病理分期的增加逐渐升高,胃癌恶病质患者血清抵抗素的升高与白介素-6呈正相关关系。

Objective To observe the changes of serum resistin level in patients with gastriccancer associated-cachexia and to investigate the relationship between resistin and interleukin-6（IL-6）.Methods Twenty-three cases of gastric cancer patients with cachexia were assigned to the cachexiagroup;23 cases of gastric cancer patients without cachexia were used as the gastric cancer group;and 23 healthy people were taken as normal controls. All the subjects were tested the sex,age,BMI and pathologicstages of cancer. The serum levels of IL-6,resistin were detected by enzyme-linked immunoabsorbent assay（ELISA）. Results Patients with pathologic stages Ⅲ and Ⅳwere more susceptible to cachexia than thosewith pathologic stages Ⅰ and Ⅱ in gastric cancer（P〈0.05）. Compared with control group,the serumresistin level and IL-6 were significantly increased in the cathexia group and gastric cancer group（P〈0.05）. Along with pathological stage increasing,the serum resistin level were significantly increased. Serumresistin level was positive correlated with IL-6 in the cachexia group（r = 0.512,P = 0.012）. Conclusion Along with pathological stage increasing in gastric cancer,the serum levels of resistin and IL-6 weresignificantly increased. Serum resistin and IL-6 were increased in the cathexia patients. And serum resistinwas positively correlated with interleukin-6 in gastric cancer cachexia.