扶正平溃汤对溃疡性结肠炎患者肠道菌群与致炎细胞因子的影响

Effects of Fuzheng Pingkui decoction on intestinal flora and proinflammatory cytokines in patients with ulcerative Colitis

目的:探究自拟扶正平溃汤对溃疡性结肠炎(UC)患者肠道菌群及致炎细胞因子的影响。方法:选取100例溃疡性结肠炎患者,按随机数字表法分为对照组和观察组各50例,分别给予美沙拉嗪和自拟扶正平溃汤治疗。比较两组患者的疗效及治疗前后肠道菌群及致炎细胞因子水平的变化情况。结果:观察组与对照组治疗总有效率依次为94%、78%,组间数据对比差异显著(P<0.05)。与治疗前对比,两组患者通过治疗乳酸杆菌、双歧杆菌含量有所升高,血清IL-4、IL-10含量均升高,而IL-6、TNF-α含量则降低,差异存在统计学意义(P<0.05)。结论:自拟扶正平溃汤治疗UC的疗效显著,既能对肠道菌群失衡进行有效改善,又能减轻肠道炎症。

Objective： To explore the effect of Fuzheng Pingkui decoction on intestinal flora and proinflammatory cytokines in patients with ulcerative colitis.Methods：100 cases of ulcerative colitis patients were randomly divided into control group and observation group, 50 cases each, were given treatment of Mesalazine or Fuzheng Pingkui decoction.The curative effect of two groups of patients and the changes of intestinal flora and proinflammatory cytokine levels before and after treatment were compared.Results：The total effective rate of the observation group and the control group were 94% and 78%, respectively, and there was significant difference between the two groups （P〈0.05）.Compared with the treatment before treatment, 2 groups of patients through the treatment of lactobacillus and Bifidobacterium increased, serum IL-4、IL-10 content increased, and IL-6, TNF-α content decreased, the difference was statistically significant （P〈 0.05）.Conclusion： Fuzheng Pingkui decoction is effective in the treatment of UC, which can improve the intestinal flora imbalance and reduce intestinal inflammation.