口服冲击剂量氟卡胺的临床电生理观察：I.对心脏传导...

CLINICAL-ELECTROPHYSIOLOGIC E FFECTS OF ORAL BOLUS FLECAINIDE ACETATE I. ON CARDIAC CONDUCTION AND PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA

观察11例阵发性室上性心动过速(PSVT)患者口服300～400mg氟卡胺的临床电生理特征。结果表明,氟卡胺对心脏传导系统有明显的抑制作用,尤以HV间期最突出。对复极无影响。用药前后PSVT诱发率由10/11降至5/11。对VA传导抑制明显。

Clinical-electrophysiologic effects of oral flecainide on 11 pateints (7 males, 4 females), aged 27～55 (averaged 42) were studied. All had PSVT. After taking 300～400 mg flecainide, P wave, P-A, A-H, and H-V interval and ORS complex were lengthened 13%, 33%, 19.9%, 78.9% and 28.5% respectively. Q-T and J-T had no significant change. It means that flecainide does not affect repolarization. FRP and EBP of atria, fast and slow pathway of AVN and ventricle were not markedly lengthened. SCL, SNRT, CSNRT and SACT were not significantly inhibited implying that patients were of normal SAN function, flecainide has no negative effect on sinus node function. PSVT was induced in 10/11 patients before and in 5/11 patients after taking the medicine.The side effect was inhibition of heart conduction. H-V was prolonged 150% in one case and QRS complex was prolonged 70% in another case.