奥美拉唑联合莫沙必利治疗反流性食管炎的临床应用分析

Analysis of Clinical Application of Omeprazole Combined with Mosapride in Treatment of Reflux Esophagitis

目的分析奥美拉唑联合莫沙必利治疗反流性食管炎的临床应用效果。方法方便选取该院2015年1月—2016年6月收治的104例反流性食管炎患者的临床资料进行回顾性分析,依据治疗方法将这些患者分为奥美拉唑联合莫沙必利组(观察组,n=52)和单纯奥美拉唑组(对照组,n=52)两组,对两组患者的临床疗效、不良反应发生情况进行统计分析。结果观察组患者治疗的总有效率96.2%(50/52)显著高于对照组82.7%(43/52)(P<0.05)。观察组患者中头晕4例,腹痛3例,腹泻1例,不良反应发生率为15.4%(8/52);对照组患者中头晕3例,乏力1例,腹痛2例,腹泻1例,不良反应发生率为13.4%(7/52)。两组患者的不良反应发生率之间的差异无统计学意义(P>0.05)。结论奥美拉唑联合莫沙必利治疗反流性食管炎的临床应用效果较单纯应用奥美拉唑好。

Objective To analyze the clinical application effect of omeprazole combined with mosapride in treatment of reflux esophagitis. Methods 104 cases of patients with reflux esophagitis admitted and treated in our hospital from January 2015 to June 2016 were selected and divided into two groups with 52 cases in each according to treatment method, the observation group were treated with omeprazole combined with mosapride, while the control group were only treated with omeprazole, and the clinical curative effect and occurrence of adverse reactions were compared between the two groups.Results The total treatment effective rate in the observation group was obviously higher than that in the control group,[96.2%（50/52） vs 82.7%（43/52）]（P〈0.05）, and in the observation group, there were 4 cases with dizziness, 3 cases with bellyache and 1 case with diarrhea, and the incidence rate of adverse reactions was 15.4%（8/52）, in the control group,there were 3 cases with dizziness, 1 case with debilitation and 2 cases with bellyache and 1 case with diarrhea, and the incidence rate of adverse reactions was 13.4%（7/52）, and the difference in the incidence rate of adverse reactions between the two groups difference was not statistically significant（P〉0.05）. Conclusion The application effect of omeprazole combined with mosapride in treatment of reflux esophagitis is better than that of simple omeprazole.