虎杖药材中蒽醌衍生物及其苷类成分的测定探讨

Study on Measurement of Quinone Derivatives and Glycosides in Rhizoma of Polygonum Cuspidatum

目的探讨虎杖药材中蒽醌衍生物及其苷类成分的测定。方法选择高效液相色谱法对虎杖药材中蒽醌衍生物及其苷类成分进行测定,并分析总结所获各项数据。结果虎杖药材中的芦荟大黄素含量偏低,大黄素甲醚、大黄酸、大黄素含量偏高,蒽酯类成分含量约为1.1%~2.8%;虎杖药材中芦荟大黄素、大黄素、大黄酸、大黄素甲醚水解后含量高于水解前。结论测定虎杖药材中蒽醌衍生物及其苷类成分,可充分保证其药用质量。

Objective To discuss the measurement of quinone derivatives and glycosides in rhizoma of polygonum cuspidatum. Methods The quinone derivatives and glycosides in rhizoma of polygonum cuspidatum were measured by the high efficiency liquid chromatography and various data were analyzed and summarized. Results The aloe-emodin content in the in the rhizoma of polygonum cuspidatum was low, and the contents of rheum emodin, rheinic acid and emodin monomethyl ether were high, and the content of quinone derivatives was about 1.1%-2.8%, and the contents of aloe-emodin, rheum emodin, rheinic acid and emodin monomethyl ether in rhizoma of polygonum cuspidatum after hydrolysis were higher than those before hydrolysis. Conclusion The measurement of quinone derivatives and glycosides in rhizoma of polygonum cuspidatum can fully ensure the medication quality.