降钙素和癌胚抗原联合检测在甲状腺髓样癌诊治中的意义

Significance of Combined Test of Calcitonin and Carcinoembryonic Antigen in Diagnosis and Treatment of Medullary Carcinoma of Thyroid Gland

目的分析降钙素和癌胚抗原联合检测在甲状腺髓样癌诊治中的意义。方法方便收取该院20例甲状腺髓样癌患者作为观察组,再收取20名健康体检者作为对照组,收取时间在2010年2月—2015年3月,实施化学发光法检测两种受检者癌胚抗原、降钙素水平。结果患者术后6 d癌胚抗原(3.12±0.89)ng/m L、降钙素水平(9.59±3.29)ng/m L与术前1 d相比显著降低,而复发时癌胚抗原、降钙素水平与术后6 d相比,显著升高(P<0.05),观察组患者降钙素(120.04±23.49)pg/m L、癌胚抗原水平(15.01±4.23)ng/m L高于对照组健康体检者(P<0.05),联合检查的敏感性显著高于单一检查(P<0.05)。结论降钙素和癌胚抗原联合检测能提高甲状腺髓样癌的敏感性,利于早期治疗和早期检测,同时还能判断患者肿瘤复发和手术效果。

Objective To analyze the significance of combined test of Calcitonin and carcinoembryonic antigen in diagnosis and treatment of medullary carcinoma of thyroid gland. Methods Convenient selection 20 cases of patients with medullary carcinoma of thyroid gland admitted and treated in our hospital were selected as the observation group, 20 cases of healthy physical examination persons were selected as the control group and the admission time was from February 2010 to March2015, and the calcitonin and carcinoembryonic antigen levels of the two groups were tested by the chemiluminescence method. Results On 6 d after operation, the carcinoembryonic antigen（3.12±0.89）ng/mL and calcitonin（9.59±3.29）ng/mL were obviously decreased compared with those in 1 d before operation, and the calcitonin and carcinoembryonic antigen levels at recurrence were obviously increased compared with those in 6 d after operation（P〈0.05）, and the calcitonin and carcinoembryonic antigen levels in the observation group were respectively（120.04 ±23.49）pg/mL and（15.01 ±4.23）ng/mL,which were higher than those in the control group（P〈0.05）, and the sensitivity of combined examination was obviously higher that of the single examination（P〈0.05）. Conclusion The calcitonin and carcinoembryonic antigen can improve the sensitivity of medullary carcinoma of thyroid gland, which is conducive to the early treatment and test, and it can also determine the tumor recurrence and operation effect.