甲基强的松龙结合常规西药治疗小儿急性肾炎的效果

Effect of Methylprednisolone and Routine Western Medicine in Treatment of Children with Acute Nephritis

目的探析小儿急性肾炎应用甲基强的松龙结合常规西药治疗的临床效果。方法方便选取该院2012年1月—2017年2月期间收治的60例急性肾炎患儿予以分析,根据病床单双号法分为两组,即单号组与双号组,各组30例。单号组予以常规西药治疗,双号组予以甲基强的松龙结合常规西药治疗,对两组临床疗效、临床症状改善时间进行统计分析。结果双号组总有效率为96.7%,高于单号组的80.0%,对比差异有统计学意义(P<0.05)。双号组水肿消失时间为(3.0±1.5)d,血尿消失时间为(2.5±1.4)d,血压恢复正常时间为(4.3±1.3)d,蛋白尿消失时间为(9.0±1.7)d,均短于单号组的(4.0±1.7)、(4.2±1.3)、(5.7±1.5)、(12.4±1.7)d,对比差异有统计学意义(P<0.05)。结论小儿急性肾炎应用甲基强的松龙结合常规西药治疗的临床效果更好,值得临床应用与推广。

Objective To study the clinical methylprednisolone and routine western medicine in treatment of children with acute nephritis. Methods 60 cases of children with acute nephritis admitted and treated in our hospital from January 2012 to February 2017 were convenient selected and divided into two groups with 30 cases in each, the odd number group and double number group were respectively treated with routine western medicine and methylprednisolone and routine western medicine, and the clinical curative effect, clinical symptoms improvement time were compared between the two groups. Results The total effective rate in the double number group was higher than that in the odd number group（96.7% vs 80.0%）,and the difference was obvious by comparison（P〈0.05）, and the edema disappearance time, hematuresis disappearance time, blood pressure returning to normal time and proteinuria disappearance time were shorter than those in the odd number group, [（3.0±1.5）d,（2.5±1.4）d,（4.3±1.3）d,（9.0±1.7）d vs（4.0±1.7）d,（4.2±1.3）d,（5.7±1.5）d,（12.4±1.7）d], and the differences were obvious by comparison（P〈0.05）. Conclusion The clinical effect of methylprednisolone and routine western medicine in treatment of children with acute nephritis is better, which is worth clinical promotion and application.