功能性消化不良患者抑郁状态与血清白介素6水平的相关性

Relationship between functional dyspepsia with depression and serum interleukin 6 level

目的探讨精神心理因素引起血清白细胞介素6(IL-6)水平变化及导致消化不良症状的可能机制。方法选取汉密尔顿抑郁量表(HAMD)评分为轻中度抑郁(≥8且≤35分)的48例功能性消化不良(FD)患者为病例组,同期HAMD评分显示没有抑郁症状(<8分)的40例FD患者为对照组。测定所有患者血清IL-6水平,进行消化不良症状评分。结果病例组血清IL-6水平、消化不良症状评分高于对照组(P<0.05);血清IL-6水平与HAMD评分、消化不良症状评分呈正相关(P<0.01);消化不良症状评分与HAMD评分呈正相关(P<0.01)。结论精神心理因素在FD发病过程中起重要作用,患者抑郁程度越重,其血清IL-6水平越高,消化不良症状也越重。

Objective To explore the possible mechanism and clinical significance of serum interleukin 6（IL-6）level and the digestive symptoms in patients caused by the mental factors.Methods Totally 48 functional dyspepsia（FD）patients with Hamilton Depression Scale（HAMD）for mild-to-moderate depression（HAMD 8points≤scores≤35points）were selected as the case group.Meanwhile,40 FD patients with no depression symptom（HAMD scores8points）in the same period were selected as the control group.The serum IL-6in two groups were measured and the indigestion symptom was scored in the case group.Results The serum level of IL-6in case group was significantly higher than that of control group（P〈0.05）.The HAMD scores and the indigestion symptom scores in case group were significantly higher than those of control group（P〈0.05）.The serum level of IL-6and HAMD scores were positively correlated（P〈0.01）.The serum level of IL-6and the indigestion symptom scores were positively correlated（P〈0.01）.The indigestion symptom scores and HAMD scores were positively correlated in case group（P〈0.01）.ConclusionThe mental factors play important role in the pathogenesis of FD.The more depressed patients are,the higher their serum IL-6are,and the more severe their dyspeptic symptoms are.